Continuous intravenous infusion of low dose of ketamine combined with morphine used for postoperative analgesia in patients with cervical spinal cord injury

Objective To compare the low-dose ketamine plus morphine incidence of clinical effects and side effects in patients with cervical spinal cord injury in postoperative intravenous analgesia, and to explore appropriate dose of ketamine. Methods Patients with spinal cord injury in 87 cases still under general anesthesia to accept Posterior spinal decompression surgery were randomly divided into three groups: M group received morphine 0 · 02mg / kg · h, MK1 group received morphine 0 · 02mg / kg · h + ketamine 0 · 02mg / kg · h, MK2 group received morphine 0 · 02mg / kg · h + ketamine 0 · 04mg / kg · h intravenous postoperative analgesia. Respectively, after the end of surgery 2h, 4h, 8h, 12h, 24h, 48h records for pain, sedation scores, the incidence of adverse reactions (itching, nausea and vomiting, psychiatric symptoms), blood oxygen saturation. Results MK2 group pain scores at each time point were significantly lower than group M and group MK1 at the same time point pain score (P0 · 01), whereas there was no significant difference (P0 · 05) between M and MK1 group. Sedation scores between the three groups was no significant difference (P0 · 05). M group, nausea, vomiting, higher (18.5%) and pruritus (7.4%) incidence, but there was no significant difference (P0 · 05) between the three groups. Patients having psychotic symptoms in the three groups were not there. Oxygen saturation value of the three groups of not less than 96% at each time point, and no significant difference (P0 · 05) between the three groups. Conclusion 0 · 04mg / kg · h intravenous ketamine in patients with spinal cord injury can be enhanced postoperative analgesia of morphine (0 · 02mg / kg · h) analgesic effect without increasing side effects.