Peri-operative low dose ketamine to reduce postoperative morphine consumption

1 clinical data of 32 patients with general anesthesia ASAⅠ ~ grade Ⅲ, aged 20 to 62 years old, no liver and central nervous system disorders, neurological disorders, diabetes, drug addiction and coronary heart disease were randomly divided into 16 cases of ketamine group K the control group C 16 cases. All patients burglary 45 ~ 60 min oral midazolam 7.5 mg, intravenous lines connected to micro-pump. K group micropump 1 g / L ketamine, saline group C, are 50 mL, all after the patients were given 0.1 mL / kg per minute continuous infusion of 0.002 mL / kg. intraoperative iv propofol 2 mg / kg, fentanyl 2 μg / kg, vecuronium 0.1 mg / kg, a good analgesic muscle relaxant tracheal intubation. 10% of intraoperative blood pressure or heart rate exceeds the base value, subject to morphine 50 μg / kg. stop pump drugs into the skin suture.