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Hearing Loss in SLE Patients Taking Hydroxychloroquine: A Literature Review of Reported Cases

Año 2021
Revista J. Rheumatol.
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Higher risk of metabolic syndrome in children and adolescents and polymorphisms in the fat mass and obesity-associated gene: a systematic review and meta-analysis.

Año 2025
Autores Song Y , Li S , Liu H , Liu X , Li J , Wang Y - Más
Revista Pediatric research
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BACKGROUND:

The relationship between polymorphisms in fat mass and obesity-associated gene (FTO) and the components of metabolic syndrome (MetS) has been explored among children and adolescents, but the results are inconsistent and inconclusive.

METHODS:

Electronic databases including Medline, Scopus, Embase, Web of Science, CNKI, and Google Scholar were searched for eligible studies, and data were extracted from each study. Standardized mean differences were calculated to examine the differences in the components of MetS between FTO genotypes.

RESULTS:

Forty-six studies (45,100 subjects), seven studies (4216 subjects), and six studies (2699 subjects) were included in the meta-analyses for FTOrs9939609, FTOrs1421085, and FTOrs17817449 polymorphisms, respectively. A-allele carriers of FTOrs9939609 polymorphism had higher levels of waist circumference (WC), systolic blood pressure, and fasting blood glucose, but lower levels of high-density lipoprotein cholesterol (HDL-C) than TT homozygotes (p < 0.05 for all). C-allele carriers of FTOrs1421085 polymorphism had higher levels of WC and lower levels of HDL-C than TT homozygotes (p < 0.05 for both). No significant associations between FTOrs17817449 polymorphism and the components of MetS were detected.

CONCLUSION:

The meta-analysis demonstrates that A allele of FTOrs9939609 and C allele of FTOrs1421085 polymorphisms confer a higher risk of MetS among children and adolescents.

IMPACT STATEMENT:

Genetic polymorphisms are closely related to metabolic syndrome in children and adolescents. The rs9939609 polymorphism in fat mass and obesity-associated gene is apparently associated with a higher risk of metabolic syndrome among children and adolescents. The findings of this study can provide reference for gene diagnosis and gene therapy of metabolic syndrome in children and adolescents.

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Understanding how sleep disorders are managed in people with asthma: A scoping review of the literature.

Año 2025
Autores Yau E , Cheung JMY , Saini B , Hughes S
Revista The Journal of asthma : official journal of the Association for the Care of Asthma
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OBJECTIVE:

People with asthma may experience sleep disturbances due to uncontrolled asthma symptoms and/or co-occurring sleep disorders. Asthma shares pathophysiological pathways with sleep disorders including insomnia and obstructive sleep apnea and the interrelationship between asthma and sleep disorders is bi-directional. Insufficient sleep in general and in people with asthma leads to worsened mental and physical health. How this is managed in people with asthma is less known.

DATA SOURCES:

This scoping review examines current literature around sleep health management employed by people with asthma and their care providers. Peer reviewed journal articles on sleep health interventions/management in adults with comorbid asthma were searched for in 4 databases, across 10 years, in a search strategy developed with medical librarians.

STUDY SELECTION:

The search led to the inclusion of 13 studies that met the review criteria, which reported sleep management interventions tested in people with sleep disorders comorbid with asthma.

RESULTS:

For people with obstructive sleep apnea and asthma, continuous positive pressure devices, oral appliances and bariatric surgery improved sleep and asthma outcomes. Improvements in other sleep disorders and asthma were shown with behavioral interventions and digital interventions including fitness tracker use.

CONCLUSION:

The limited studies retrievable on this topic suggest management of sleep disorders in people with asthma is an under-researched area. Future research directed at how and when to assess sleep management in people with asthma will better inform specific guidelines and achieve improved sleep health in this population.

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A narrative review of medical and surgical nurses' attitudes and perceptions when caring for patients with a secondary diagnosis of mental illness.

Año 2025
Revista Nurse education today
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BACKGROUND:

Medical and surgical nurses are responsible for prioritising patient-centred and holistic care. It is necessary for nurses to possess the relevant knowledge and interpersonal skills to deliver culturally responsive, compassionate, safe, and effective care to patients who have comorbidities inclusive of mental health conditions. It is important to acknowledge reported experiences of mistreatment, and discrimination from patients with a secondary diagnosis of mental illness (SDMI). To counter poor nursing practice and disrupt discriminatory attitudes and perceptions of medical and surgical nurses it is necessary for nurse educators to embed anti-discriminatory and social justice pedagogy into pre-registration nurse education.

AIM:

This review seeks to explore and identify the attitudes and perceptions of medical and surgical nurses when caring for patients with a secondary diagnosis of mental illness.

METHOD:

This literature review used a systematised approach to retrieve evidence that assessed the attitudes and perceptions of nurses when caring for patients with a SDMI in medical and surgical ward environments. Five databases were searched (PubMed, Embase, Clinical Knowledge Network, Cochrane and PsycInfo) between 2011 and 2023. Thematic synthesis was conducted on studies that met the following inclusion criteria: a) nurses as research participants who have cared or currently care for patients with a SDMI, b) nurse's attitudes, perceptions, feelings, and experiences, and c) surgical and medical inpatient units. Studies were excluded if they were: a) systematic reviews; b) reviews; c) literature not in English and d) grey literature.

RESULTS:

8 peer reviewed articles were included. Nurses' attitudes and perceptions were found to be stigmatising and discriminatory towards patients with a SDMI and negatively impacted their care. The themes from the retrieved evidence suggests that nurses commonly viewed patients with a SDMI as risky, unpredictable, fear inducing, and created feelings of futility and reduced professional satisfaction. Nurses felt unprepared when caring for this patient group. Several factors that negatively impacted nurses' preparedness included their previous education in mental health, personal experience with mental health issues, and social demographic variables.

CONCLUSION:

Education reform in nursing is necessary to improve healthcare advocacy and safety for patients with a SDMI, cared for in medical and surgical nursing environments. This can only be achieved through a nursing workforce cognisant with human rights and social justice principles. Fair, just, and compassionate nursing responses to patient with a SDMI recognizes critical concepts of mental health recovery, hope and anti-discriminatory pedagogy in nurse education. Critical social justice approaches in curriculum provides nursing students with lessons to understand complex health issues, and national and global disparities in health that exist according to social, cultural, racial and political determinants of health and wellbeing. Recommendations to address these concepts include in-service mental health training focusing on clinical knowledge, clinical mentorship, anti-stigmatising training and simulation-based exercises based upon social justice principles in pre-registration nurse education curriculum.

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Micro-nanoplastic induced cardiovascular disease and dysfunction: a scoping review.

Año 2025
Revista Journal of exposure science & environmental epidemiology
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BACKGROUND:

The human bioaccumulation of micro- and nano-plastics (MNPs) is increasingly being recognised in the aetiology and pathophysiology of human disease.

OBJECTIVE:

This systematic scoping review aims to provide a comprehensive investigation of studies examining the impacts of MNPs on the human cardiovascular system.

METHODS:

Five databases (PubMed, SCOPUS, CINAHL, Web of Science and EMBASE) were systematically searched.

RESULTS:

Forty-six articles were identified, 13 of which investigated the presence of MNPs within the human cardiovascular system, including atherosclerotic plaques, saphenous vein tissue, thrombi and venous blood. The effect of MNPs on cell lines suggest MNPs are cytotoxic, immunotoxic, and genotoxic.

SIGNIFICANCE:

The findings of this review, when evaluated together with additional studies utilising animal models, suggest MNPs may contribute to global cardiovascular morbidity and mortality. In particular, the ability of MNPs to induce endothelial damage, oxy-LDL formation, foam cell development and apoptosis, as well as to alter the clotting cascade, has potential implications for vascular diseases. In addition, MNPs may play a role in the aetiology and progression of congenital heart abnormalities, infective pathologies and cardiomyopathies. Despite an increasing awareness of the ability for MNPs to result in cardiovascular disease and dysfunction, a limited amount of research has been conducted to date characterising the presence of MNPs in the human cardiovascular system. Reseach is required to understand the extent of this rapidly emerging issue and to develop strategies that will support clinicians to appropriately manage and educate their patients in the future.

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Comparisons between partial and total sialoadenectomy for benign submandibular gland tumors: A systematic review and meta-analysis.

Año 2025
Autores Dou K , Zhang T , Yang B , Zhao Z
Revista Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
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This study aimed to compare postoperative efficacy and functional outcomes between partial sialoadenectomy (PS) and total sialoadenectomy (TS) in patients with benign submandibular gland (SMG) tumors. We systematically searched PubMed, Web of Science, EmBase, Cochrane Library, China Biomedical Literature, and CNKI from inception to 2024, following PICOS criteria (Population: Adults with benign SMG tumors; Intervention: PS; Comparison: TS; Outcomes: Salivary function, neurological complications, recurrence, operative duration, dry mouth, infection/hematoma; Study design: RCTs/observational studies with ≥ 6-month follow-up). The protocol was prospectively registered (PROSPERO CRD42024595824). Risk ratios (RR) were calculated for dichotomous outcomes, and weighted mean differences (WMD) for continuous outcomes, using random-effects models. Heterogeneity was quantified by I2 statistics and Q tests. Sensitivity analyses included leave-one-out methods, and publication bias was assessed via funnel plots and Egger's test. The analysis of findings was guided by the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) framework to evaluate evidence certainty, while also considering the size of intervention effects in alignment with GRADE methodology. From 1014 screened studies, 7 studies (3 RCTs, 4 cohort studies) involving 399 patients (PS: n = 188; TS.: n = 211) were included. PS demonstrated superior static saliva flow (WMD = 0.24, 95 %CI 0.13, 0.35)and reduced neurological complications (RR = 0.22, 95 %CI 0.10, 0.49), operative duration (WMD = -14.19, 95 %CI -23.4, -4.99), and dry mouth (RR = 0.12, 95 %CI 0.03, 0.49). However, there were no significant differences between the two groups in stimulated saliva flow (WMD = 0.01, 95 %CI -0.01, 0.04), tumor recurrence (RR = 3.23, 95 %CI 0.13, 77.99), postoperative infection (RR = 0.25, 95 %CI 0.03, 2.26), and postoperative hematoma (RR = 0.36, 95 %CI 0.08, 1.72). GRADE revealed moderate-certainty evidence for functional outcomesbut low/very low certainty for neurological complications, recurrence, operative duration, dry mouth, postoperative infection and hematoma. The current results demonstrate that partial sialoadenectomy offers significant advantages over traditional total sialoadenectomy.It is recommended that clinicians consider adopting new surgical procedures for the treatment of benign tumors of the submandibular gland in the future.

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Prevalence and influencing factors of kinesiophobia after total knee arthroplasty: a systematic review and meta-analysis.

Año 2025
Autores Du X , Shao Y , Xue J , Kong J
Revista Journal of orthopaedic surgery and research
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BACKGROUND:

Knee osteoarthritis is a common degenerative disease in the elderly, and total knee arthroplasty is an effective treatment for end-stage knee joint diseases. However, kinesiophobia after surgery can impede patients' rehabilitation and affect the recovery of knee joint function. There are differences in the research on its related influencing factors.

OBJECTIVES:

This meta-analysis examined the prevalence and risk factors of kinesiophobia after TKA.

METHODS:

Pubmed, The Cochrane Library, China National Knowledge Infrastructure (CNKI), Embase, Web of Science on the prevalence and risk factors of kinesiophobia after TKA was searched in science, MEDLINE and other databases. Duplicate literature, low quality literature, literature with inconsistent observation indicators, and literature without full text were excluded. Two independent researchers used Newcastle-Ottawa Scale (NOS) to evaluate the quality of the included literature. After data extraction, Meta-analysis was performed using Stata17.0.

RESULTS:

A total of 11 articles involving 4039 cases were included in this meta-analysis to assess the prevalence of kinesiophobia after TKA. The overall prevalence was found to be 35% (95% CI.: 27-44%). Subgroup analyses revealed varying prevalence rates based on age, education, income, and residence, with the highest prevalence observed in individuals under 65 years and those with lower levels of education and income. Key factors influencing the prevalence of kinesiophobia included pain (OR = 2.313, 95% CI.: 1.556-3.07), low social support (OR = 1.681, 95% CI.: 1.000-2.361), and negative coping strategies (OR = 1.344, 95% CI.: 1.165-1.523).

CONCLUSION:

The prevalence of kinesiophobia after TKA is high. There are differences in the prevalence of kinesiophobia among people with different places of residence, different education levels, and different monthly incomes. At the same time, it is affected by many factors such as postoperative pain, low social support, low self-efficacy, negative coping, old age, and low education level.

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Experiences of Family Caregivers of Children Aged 1-23 Months Who Have Received Pediatric Palliative Care: A Systematic Review With Qualitative Metasynthesis.

Año 2025
Revista Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing
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INTRODUCTION:

Family caregivers of children receiving pediatric palliative care (PPC) play a crucial role in their care and wellbeing, especially during the early stages of life.

OBJECTIVE:

To explore the experience of family caregivers of children aged 1-23 months who are receiving pediatric palliative care (PPC).

METHODS:

A systematic review of qualitative studies was conducted using the databases PubMed, Scopus, Web of Science, CINAHL, PsycINFO, and Cuiden. The studies were appraised using the Critical Appraisal Skills Programme tool. The selected studies were synthesized using Noblit and Hare's meta-ethnographic method.

RESULTS:

Eleven studies, 169 themes, 36 metaphors and four main themes were identified. Caregivers develop coping strategies related to meaning-making, faith, maintaining hope, and decision-making abilities. They perceive limited time with the child due to structural constraints and the child's deteriorating health, which sometimes prevents them from recognizing their child's identity. Caregivers strive to remain united and rebuild the daily family life they long for, but face challenges related to self-care, maintaining employment, and caring for siblings and their partner. In many cases, they are unsatisfied with the care they receive, attributed to a lack of technical training and understanding of the principles of pediatric palliative care (PPC) by healthcare staff, poor communication skills, and inadequate coordination. Caregivers highlight the role of nurses and the PPC team, advanced care planning, and post-mortem care as positive aspects.

DISCUSSION/CONCLUSION:

Caregivers' experiences reveal coping strategies, active decision-making, constant challenges, healthcare interactions, and a need for improved comprehensive support.

CLINICAL RELEVANCE:

This study underscores the importance of addressing the unique needs of family caregivers of children aged 1-23 months receiving pediatric palliative care (PPC), highlighting their struggles with social isolation, neglected self-care, and disrupted family life. Healthcare providers should prioritize age-specific approaches to PPC, focusing on improving communication, care coordination, and understanding of palliative care principles to better support these caregivers.

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A Meta-Analysis on the Impact of Induction Chemotherapy on Survival Outcomes for Sinonasal Squamous Cell Carcinoma.

Año 2025
Autores Goh RS , Keng CGH
Revista Journal of rhinology : official journal of the Korean Rhinologic Society
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BACKGROUND AND OBJECTIVES:

Malignant neoplasms of the nasal cavity and paranasal sinuses are an aggressive form of tumour that tends to be diagnosed at a locoregionally advanced stage. Among its various histological subtypes, squamous cell carcinomas (SCC) are the most common form of sinonasal cancer, with approximately 50%-60% of sinonasal malignancies being SCC. This review aims to investigate the impact of induction chemotherapy on survival outcomes for patients undergoing cancer care for sinonasal squamous cell carcinomas (SNSCC).

METHODS:

Two reviewers independently assessed 2,118 studies pooled from four bibliographic databases, namely MEDLINE, Embase, Cochrane Central Register of Controlled Trials and Web of Science and hand-searched grey literature. This systematic review and meta-analysis was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. As this was a time-to-event analysis, hazard ratios (HRs) and standard errors were derived from individual studies and pooled together for analysis. If these values were not available directly, statistical methods were used to indirectly extract the required data via Kaplan-Meier curves or via the p-value and the numbers of events.

RESULTS:

Results suggest a notable improvement in overall survival (HR=0.56, 95% confidence interval [CI]=[0.36, 0.86], p<0.009) and a promising improvement in disease-free survival (HR=0.82, 95% CI=[0.62, 1.08], p=0.16) for patients who underwent induction chemotherapy in addition to definitive treatment for SNSCC.

CONCLUSION:

Our findings add to existing literature by providing a precise pooled estimate of the beneficial effects, revealing that induction chemotherapy is not just a viable add-on to traditional treatment regimens but also improves survival outcomes when compared to definitive local therapy as a standalone treatment. Clinicians should consider incorporating induction chemotherapy as a treatment option for locoregionally advanced SNSCC.

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A systematic literature review of the efficacy of acaricidal plants, plant extracts, and tick assays used against dog-associated ticks.

Año 2025
Revista Acta tropica
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Dogs are an integral part of many households and important companion animals to humans. Their inquisitive and exploratory behaviour leads them to roam natural environments, making them susceptible to tick infestations that can also be transmitted to humans. To control these ticks, various plant extracts have been evaluated for their efficacy as acaricides and/or repellents against various species. This study was aimed at consolidating the data that has been published in terms of the plant species that have shown efficacy against ticks that parasitize dogs, it further evaluated the methods used in these formulations. A keyword-Boolean strategy was created to extract a total of n = 103 articles that were included in the study. The leading countries in terms of the global distribution of acaricidal plant investigation outputs were Brazil at 23%, India at 17% and Turkey at 7%. A total of n = 13 tick species were used in the evaluated studies. The dog tick Rhipicephalus sanguineus was the most widely used for efficacy testing at 43% frequency. The Lamiaceae plant family had the highest frequency for reported use across the evaluated studies at 18%, this was followed by the family Asteraceae at 11%. Adult immersion test, larval packet test and larval immersion test were the most preferred assays for acaricidal efficacy studies. Leaves were the most preferred plant parts utilized for crude plant metabolites extraction (n = 43), while essential oils were the most highly reported extracts (n = 60). Lastly, extracts were primarily subjected to Gas chromatography for analysis of the plant compounds (n = 38). This paper gives the current global status of potential acaricidal plants utilized against ticks parasitizing dogs.

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