Epistemonikos: قاعدة بيانات لأفضل الرعاية الصحية القائمة على الأدلة

Pregnancy-associated plasma protein-A (PAPPA) has been reported to regulate the activity of insulin-like growth factor (IGF) signal pathway through proteolytic degradation of IGF binding proteins (IGFBPs) thereby increasing the local concentration of free IGFs available to receptors. In this study we found that PAPPA is secreted from two out of seven lung cancer cell lines examined. None of immortalized normal bronchial epithelial cells (HBE) tested secrets PAPPA. There is no correlation between expression level and secretion of PAPPA in these cells. A cell line over-expressing PAPPA accompanied with secretion shows no notable changes in proliferation under cell culture conditions in vitro, but displays significantly augmentation of tumor growth in vivo in a xenograft model. In contrast, a cell line over-expressing PAPPA without secretion exhibits reduction of tumor growth both in vitro and in vivo. Down-regulation of PAPPA expression and secretion by RNAi knockdown decreases tumor growth after implanted in vivo. The tumor promoting activity of PAPPA appears to be mediated mainly through augmentation of the IGF signaling pathway as indicated by notable increases in downstream Akt kinase phosphorylation in tumor samples. Our results indicate that PAPPA secretion may play an important role in lung cancer growth and progression.

Immediate effect of acupuncture on the sleep pattern of patients with obstructive sleep apnoea.

Authors » Freire AO , Sugai GC , Togeiro SM , Mello LE , Tufik S

Journal » Acupuncture in medicine : journal of the British Medical Acupuncture Society

Year » 2010

Links » Pubmed DOI

This article is included in 1 Systematic review Systematic reviews (1 reference)

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BACKGROUND: Most patients with obstructive sleep apnoea (OSA) do not tolerate treatment with nasal continuous positive airway pressure, the 'gold standard' treatment for this condition. It was shown in a pilot study that acupuncture was more effective than placebo treatment (sham acupuncture) in producing significant changes in the respiratory events assessed by polysomnography (PSG). OBJECTIVES: To investigate the immediate effect of manual acupuncture (MA) and electroacupuncture (EA) on the sleep pattern of patients presenting with moderate OSA. METHODS: 40 patients with an Apnoea-Hypopnoea Index (AHI) of 15-30/h were randomly allocated to MA treatment (n=10), EA 10 Hz treatment (n=10), EA 2 Hz treatment (n=10) and a no-treatment control group (n=10). The patients received MA or EA (2 or 10 Hz) just before the PSG study at 20:00. RESULTS: The AHI (p=0.005; p=0.005), the Apnoea Index (p=0.038; p=0.009) and the respiratory events (p=0.039; p=0.014) decreased significantly in the MA and EA 10 Hz groups, respectively (AHI (21.9, 11.2), Apnoea Index (5.15, 0.7), respiratory events (120.5, 61.0) in the MA group before and after. AHI (20.6, 9.9), Apnoea Index (8.2, 0.3), respiratory events (117.0, 56.0) in the EA 10 Hz group before and after). The micro-arousals decreased only in the MA group (146.0 vs 88.5, p=0.0002). There were no significant changes in the EA 2 Hz group or in the control group. CONCLUSION: A single session of either MA or EA 10 Hz had an acute effect in reducing the AHI as well as the number of nocturnal respiratory events of patients presenting with moderate OSA.

[A study on differences of curative effects of acupuncture and nCPAP for treatment of OSAHS].

Authors » Bo C , Zhang XS , Huang H , Jia Y , Xie XM

Journal » Zhongguo zhen jiu = Chinese acupuncture & moxibustion

Year » 2008

Links » Pubmed

This article is included in 1 Systematic review Systematic reviews (1 reference)

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OBJECTIVE: To compare curative effects of acupuncture and nasal continuous positive airway pressure (nCPAP) on obstructive sleep apnea-hypopnea syndrome(OSAHS), and to explore the characteristics and advantages of acupuncture in treatment of this disease. METHODS: Sixty-six cases of OSAHS were randomly divided into an acupuncture group (n = 44) treated by acupuncture at Lianquan (CV 23) and Tianrong (SI 17) etc., and a nCPAP group (n = 22) treated by nCPAP. Indexes of respiration, blood oxygen and sleep were monitored before, during and after treatment. RESULTS: Compared with those before treatment, no significant differences of these indexes were found in the acupuncture group during treatment (P > 0.05), but hypopnea index (HI), apnea-hypopnea index (AHI), the maximal apnea duration, the maximal hypopnea duration, sleep time spent when SaO2 was below 90% (SaO2 < 90%T) and the microarousal index improved significantly at the end of treatment (P < 0.05 or P < 0.01); while all the indexes improved significantly in the nCPAP group during treatment (P < 0. 01), but the therapeutic effect was not maintained at the end of treatment with no significant difference as compared with those before treatment. The therapeutic effect in the nCPAP group was better than that in the acupuncture group during the treatment (P < 0.05 or P < 0.01), but no significant difference of the therapeutic effect was found between the two groups at the end of treatment (P > 0.05). CONCLUSION: The therapeutic effect of nCPAP on OSAHS produces during treatment and the therapeutic effect of acupuncture produces after treatment, indicating they possibly have different mechanisms.

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