Primary studies included in this broad synthesis

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McGill University Health Center [provisional name] (Nabilone for fibromyalgia [provisional name])

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Primary study

Unclassified

Possible hypnotic effect of cannabidiol on human. preliminary study

Zeitung Ciência e Cultura
Year 1979

Dieser Artikel ist in enthalten 1 Systematic review Systematic reviews (1 reference) 1 Broad synthesis Broad syntheses (1 reference)

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Primary study

Unclassified

(-) Delta 9 THC as an hypnotic. An experimental study of three dose levels.

Autoren Cousens K , DiMascio A
Zeitung Psychopharmacologia
Year 1973
Links Pubmed DOI

Dieser Artikel ist in enthalten 2 Systematic reviews Systematic reviews (2 references) 1 Broad synthesis Broad syntheses (1 reference)

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(−)δ9 THC was found to significantly decrease the time it takes to fall asleep in physically healthy insomniacs. Once asleep, interruptions of sleep were not significantly altered over the whole night. The (−)δ9 THC tended to be associated with some decrease in awakenings in the first half of the night. The primary side effect experienced by the subjects at all dose levels in the Pre-Sleep phase was temporal disorganization and mood alterations. There was an increase in intensity of side effects and number of subjects affected with increasing dosage. The most significant side effect, however, was a “hangover” phenomenon, or continued “high” the next day, with some residual of temporal disorganization. It increased in intensity and duration with increase in dosage. This “hangover” seems severe enough to eliminate the consideration of the 30 mg dose range of (−)δ9 THC for clinical use as an hypnotic.