Dronabinol and prochlorperazine in combination for treatment of cancer chemotherapy-induced nausea and vomiting.

Category Primary study
JournalJournal of pain and symptom management
Year 1991
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This article is included in 10 Systematic reviews Systematic reviews (10 references) 3 Broad syntheses Broad syntheses (3 references)

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  • Lane [provisional publication thread name] (2 documents)
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Tested dronabinol (DAB) and prochlorperazine (PCZ) alone and in combination in a randomized, double-blind, parallel group, multicenter study. 62 patients (aged 20–68 yrs) were randomized to receive either (1) DAB 10 mg every 6 hrs plus placebo; (2) placebo plus PCZ 10 mg every 6 hrs; or (3) DAB and PCZ, each 10 mg every 6 hrs. Antiemetic treatment was begun 24 hrs before and continued for 24 hrs after the last dose of chemotherapy. Results confirm that patients respond better to a combination of DAB and PCZ than to PCZ alone. The combination was an effective antiemetic regimen when given with a variety of commonly used chemotherapeutic drugs. (PsycINFO Database Record (c) 2018 APA, all rights reserved)
Epistemonikos ID: 027a9232593c6e1910cd2a1214977273286bb146
First added on: Dec 20, 2014