Primary studies included in this systematic review

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Primary study

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Electroconvulsive therapy augmentation in clozapine-resistant schizophrenia: A prospective, randomized study

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Journal The American journal of psychiatry
Year 2015
Links Pubmed DOI

This article is included in 3 Systematic reviews Systematic reviews (3 references) 1 Broad synthesis Broad syntheses (1 reference)

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Objective: Up to 70% of patients with treatment-resistant schizophrenia do not respond to clozapine. Pharmacological augmentation to clozapine has been studied with unimpressive results. The authors examined the use of ECT as an augmentation to clozapine for treatment-refractory schizophrenia. Method: In a randomized single-blind 8-week study, patients with clozapine-resistant schizophrenia were assigned to treatment as usual (clozapine group) or a course of bilateral ECT plus clozapine (ECT plus clozapine group). Nonresponders from the clozapine group received an 8-week open trial of ECT (crossover phase). ECT was performed three times per week for the first 4 weeks and twice weekly for the last 4 weeks. Clozapine dosages remained constant. Response was defined as ≥40% reduction in symptoms based on the psychotic symptom subscale of the Brief Psychiatric Rating Scale, a Clinical Global Impressions (CGI)-severity rating <3, and a CGI-improvement rating ≤2. Results: The intent-to-treat sample included 39 participants (ECT plus clozapine group, N=20; clozapine group, N=19). All 19 patients from the clozapine group received ECT in the crossover phase. Fifty percent of the ECT plus clozapine patients met the response criterion. None of the patients in the clozapine group met the criterion. In the crossover phase, response was 47%. There were no discernible differences between groups on global cognition. Two patients required the postponement of an ECT session because of mild confusion. Conclusions: The augmentation of clozapine with ECT is a safe and effective treatment option. Further research is required to determine the persistence of the improvement and the potential need for maintenance treatments.

Primary study

Unclassified

Clinical analysis on MECT combined with ziprasidone in treatment of patients with refractory schizophrenia

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Authors Jiang, Zhengwei
Journal Journal of Clinical and Experimental Medicine
Year 2013
Links DOI med.wanfangdata.com

This article is included in 1 Systematic review Systematic reviews (1 reference) 1 Broad synthesis Broad syntheses (1 reference)

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OBJECTIVE: MECT combined with ziprasidone treatment refractory schizophrenia clinical effects and adverse reactions, provide the basis for clinical treatment of refractory schizophrenia. METHODS: treated 162 patients with refractory schizophrenia were randomly divided into two groups, the treatment group were treated with MECT combined with ziprasidone treatment, the control group with clozapine plus ziprasidone treatment. respectively before and after treatment 1,2,4 and 8 weeks using the brief psychiatric Rating scale (BPRS) and TESS (TESS) to assess the clinical efficacy and adverse reactions, and compare the clinical efficacy results in 2, 4 and 8 compare four time points, treatment group BPRS scores were significantly lower than the control group, the difference was statistically significant (P <0.05), the total clinical efficiency comparison, the total effective rate was 82.7%, 70.4% in the control group, the difference was statistically significant (P <0.05); the adverse reactions, the treatment group 2 and 4 weeks TESS scores compared with control group showed no significant difference (P> 0.05), but the treatment group 8 weeks TESS scores were significantly lower than the control group, the difference was statistically significant (P <0.05). CONCLUSION: MECT combined with ziprasidone treatment of refractory schizophrenia clinical effect significantly superior to clozapine plus ziprasidone treatment and poor reactions, has a broad clinical application.

Primary study

Unclassified

Efficacy study of olanzapine combined with MECT on the treatment of refractory schizophrenia

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Authors Wang, Fei , Guo, Dingwang
Journal Chinese Journal of Clinical Rational Drug Use
Year 2013
Links DOI wanfangdata.com

This article is included in 1 Systematic review Systematic reviews (1 reference) 1 Broad synthesis Broad syntheses (1 reference)

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OBJECTIVE: To observe the Tsavo olanzapine combined with modified electroconvulsive therapy refractory schizophrenia patients. METHODS: in our hospital in January 2011 - December 2012 admitted 72 patients with refractory schizophrenia were randomly divided into control and experimental groups, each group of 36 cases. Control group were receiving olanzapine; improved experimental group received electric shock treatment on this basis. Comparison of the two groups of treatment. RESULTS: were cured in 9 cases, 12 cases markedly improved in 12 cases, 4 cases; the control group healed in 3 cases, 8 cases were markedly improved in 11 cases, 12 cases, two groups the difference was statistically significant (P0.05 ). Symptoms of adverse reactions in the experimental group salivation, lethargy, sinus tachycardia, and constipation were significantly lower than the control group, the difference was statistically significant (P0.05). CONCLUSION: olanzapine combined modified electroconvulsive therapy refractory schizophrenia, with a more satisfactory clinical efficacy, high clinical value.

Primary study

Unclassified

A control study of antipsychotic combined with MECT in treatment-resistant schizophrenia

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Journal Journal of Clinical Psychosomatic Diseases
Year 2013
Links DOI med.wanfangdata.com

This article is included in 1 Systematic review Systematic reviews (1 reference) 1 Broad synthesis Broad syntheses (1 reference)

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OBJECTIVE: To evaluate the clinical efficacy of antipsychotics combined with non-refractory schizophrenia modified electric convulsive therapy. METHODS: 90 patients with refractory schizophrenia were randomly divided into two groups, study group of 50 patients in the control group of 40 patients, two groups conventional antipsychotics were applied, the joint Study group modified electroconvulsive shock treatment on this basis, 12 weeks. positive and negative Syndrome scale to assess the clinical efficacy. the results of each study group therapy session the positive and negative symptom scale scores significantly lower than the control group (P <0.05); the treatment of 12 weeks, the study group was 52.0% efficiency, the total efficiency of 88.0%, the control group were 27.5%, 72.5%, the study group was efficient, total effective rate was significantly higher than that the control group (P <0.05). CONCLUSION: antipsychotics joint MECT treatment of refractory schizophrenia significant, rapid onset was significantly better than with antipsychotic drugs.

Primary study

Unclassified

Comparative study of quetiapine combined MECT on the treatment of female refractory schizophrenia

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Authors Wang, Youbing
Journal Contemporary Medicine
Year 2012
Links DOI med.wanfangdata.com

This article is included in 1 Systematic review Systematic reviews (1 reference) 1 Broad synthesis Broad syntheses (1 reference)

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OBJECTIVE: To investigate quetiapine combined modified electric convulsive therapy (MECT) clinical efficacy and safety of women with refractory schizophrenia. METHODS: 62 female patients with refractory schizophrenia were randomly divided into two groups, the study group (31 cases ), oral quetiapine based on the use MECT treatment and control group (31 cases), clozapine treatment, 8 weeks, before treatment and at 2 weeks, 4 weeks, 6 weeks, 8 weeks using the positive and negative Syndrome scale, to assess the clinical efficacy, adverse side effects rating scale from 2 weeks before the results of the treatment of positive symptoms factor score decreased significantly compared with treatment (P <0.05);. treatment from 4 weekend, two positive and negative symptoms of the amount table total score and factor scores than those there before treatment significantly decreased (P <0.05 or 0.01); the treatment of various periods Rating study group than the control group decreased significantly, but there was no significant difference (P> 0.05); the treatment of 8 weeks, study group was 71.2%, the control group was 66.7%, there was no significant difference (P> 0.05). CONCLUSION: quetiapine combined MECT treatment of female refractory schizophrenics with clozapine rather, but comparing clozapine faster, safer, and medication compliance is greatly improved.

Primary study

Unclassified

Observational study of the Efficacy of MECT combined olanzapine on the treatment of refractory schizophrenia

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Journal People’s Military Surgeon
Year 2012
Links www.zhiyuanbao.net

This article is included in 1 Systematic review Systematic reviews (1 reference) 1 Broad synthesis Broad syntheses (1 reference)

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OBJECTIVE: To observe the MECT (MECT) combined with olanzapine treatment of refractory schizophrenia. METHODS: 84 cases of refractory schizophrenia were randomly divided into observation group and control group 42 cases. The control group was treated with olanzapine treatment, observation group MECT combined with olanzapine treatment. To compare the two groups total effective, positive symptoms and negative syndrome scale (PANSS), symptom scale (TESS) scores and adverse reactions during treatment. Results: The total efficiency of 95.2%, 69.0% higher than the very significant (P <0.01). 2,4,6,8 weeks after treatment, both groups PANSS total score, positive symptoms, negative symptoms and general pathology scores were significantly or very significantly lower than before treatment (P <0.05, P <0.01); treatment 4,6 eight weeks later, the observation group positive symptoms scores was significantly or very significantly lower than the control group (P <0.05, P <0.01); after 6,8 weeks of treatment, the observation group general pathology scores were significantly lower than the control group (P < 0.05). TESS scores of the two groups and adverse reactions, the difference was not significant (P> 0.05). CONCLUSION: MECT combined with olanzapine in the treatment of refractory schizophrenia effective than olanzapine alone.

Primary study

Unclassified

Comparative analysis of MECT treatment on refractory schizophrenia

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Authors Chen, Derong
Journal Xinjiang Medical Journal
Year 2012
Links DOI med.wanfangdata

This article is included in 1 Systematic review Systematic reviews (1 reference) 1 Broad synthesis Broad syntheses (1 reference)

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OBJECTIVE: To investigate the MECT (MECT) combined clozapine difficult clinical effect and safety of active schizophrenia METHODS: 71 patients with refractory schizophrenia were randomly divided into two groups, study group of 36 patients in the more small application on the basis of joint use of clozapine MECT treatment control group of 35 patients, only clozapine therapy;. for a 12-week clinical controlled study was before treatment and the use of positive weekend of 8 and 12 and negative Syndrome scale (PANSS) and symptom scale (TESS) to evaluate the clinical efficacy and adverse reactions: after 12 weeks of treatment, clinical research group, the total effective rate was 61.8% in the control group clinical total effective rate was 29.1%. , there was a significant difference (P <0.05 or P <0.01) groups; Study group lethargy, salivation, constipation, weight gain, abnormal electrocardiogram, leukopenia and other factors less than the control group, the difference was significant (P <0.01 or P <0.05) CONCLUSION: MECT combined clozapine effective refractory schizophrenia, mild adverse reactions, suitable for clinical use.

Primary study

Unclassified

Intractable mental disease clinical classification analysis

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Authors [Duo, J]
Journal Medical Information
Year 2011
Links DOI med.wanfangdata.com.

This article is included in 1 Systematic review Systematic reviews (1 reference) 1 Broad synthesis Broad syntheses (1 reference)

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OBJECTIVE: To investigate the olanzapine combined with no clinical efficacy in refractory schizophrenia modified electric convulsive therapy : our hospital in July 2006 - May 2009 were treated 60 patients with refractory schizophrenia information, were randomly divided into treatment group (30 cases) and control group (30 cases) and control group were treated with olanzapine treatment, patients taking olanzapine based on the use modified electric convulsive therapy (MECT), continuous treatment 12 weeks, using a positive and negative symptoms rating scale efficacy results in patients with: the difference was statistically significant efficacy in patients (p <0.05) groups had no significant adverse reactions and safe CONCLUSION: MECT combined with olanzapine in the treatment of refractory schizophrenia, clinical results were satisfactory, safe, worthy of promotion.

Primary study

Unclassified

Clinical study of MECT on 100 patients with refractory schizophrenia

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Authors Ding, Ling , Ma, YanJuan
Journal Chinese Community Doctors
Year 2011
Links DOI med.wanfangdata.com

This article is included in 1 Systematic review Systematic reviews (1 reference) 1 Broad synthesis Broad syntheses (1 reference)

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OBJECTIVE: To investigate the MECT (MECT) clinical efficacy and safety of refractory schizophrenia (TRS) patients METHOD: Choose treated 200 patients with refractory schizophrenia patients were randomly divided into control group . the treatment group and control group with conventional therapy, the treatment group on the basis of conventional therapy with MECT treatment, treatment groups were compared: after 4 weeks of treatment treatment group PANSS scale score was significantly lower than the control group (P <0.05); the treatment group was 72%, the control group was 63% of the treatment group was significantly higher than the treatment group 2 patients developed short-term memory damage, and by reducing the dosage. after the frequency of treatment, in 3 to 5 days to resume normal control group patients No serious complications CONCLUSION: MECT treatment carried out on the basis of conventional drug treatment, the treatment of refractory schizophrenia is a safe and effective method.

Primary study

Unclassified

Analysis of efficacy and safety of clozapine combined with MECT treatment on refractory schizophrenia

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Journal Medical Journal of Chinese People's Health
Year 2011
Links DOI med.wanfangdata.com

This article is included in 1 Systematic review Systematic reviews (1 reference) 1 Broad synthesis Broad syntheses (1 reference)

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OBJECTIVE: Learn without electricity shock (MECT) the efficacy of the treatment of schizophrenia and seizures security METHODS: 60 patients with schizophrenia were randomly divided into two groups of 30 patients in each treatment group and clozapine combined with electric shock, the control group. single with clozapine groups continued for 8 weeks, respectively, before treatment and 10 modified electric convulsive therapy using BPRS scale after the assessment of efficacy results: The treatment group was 60% efficiency, efficiency of 80%; the control group. effective rate of 40%, a significant difference before and after each treatment 66.7% efficiency (P <0.01), two groups before treatment had no significant difference (P> 0.05), there was a significant difference (P <0.01) CONCLUSION: after treatment.: clozapine combined with electric-shock therapy is superior to clozapine therapy alone rapid onset, safety, is one of the available clinical methods.