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Continuous infusion or bolus injection of loop diuretics for congestive heart failure?

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Authors Zepeda P , Rain C , Sepúlveda P
Journal Medwave
Year 2016
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This article includes 4 Systematic reviews Systematic reviews (4 references) 12 Primary studies Primary studies (12 references)

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Loop diuretics are widely used in acute heart failure. However, there is controversy about the superiority of continuous infusion over bolus administration. Searching in Epistemonikos database, which is maintained by screening 30 databases, we identified four systematic reviews including 11 pertinent randomized controlled trials overall. We combined the evidence using meta-analysis and generated a summary of findings following the GRADE approach. We concluded continuous administration of loop diuretics probably reduces mortality and length of stay compared to intermittent administration in patients with acute heart failure.

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What are the effects of hypertonic saline plus furosemide in acute heart failure?

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Authors Zepeda P , Rain C , Sepúlveda P
Journal Medwave
Year 2015
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This article includes 2 Systematic reviews Systematic reviews (2 references) 10 Primary studies Primary studies (10 references)

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In search of new therapies to solve diuretic resistance in acute heart failure, the addition of hypertonic saline has been proposed. Searching in Epistemonikos database, which is maintained by screening 30 databases, we identified two systematic reviews including nine pertinent randomized controlled trials. We combined the evidence and generated a summary of findings following the GRADE approach. We concluded hypertonic saline associated with furosemide probably decrease mortality, length of hospital stay and hospital readmission in patients with acute decompensated heart failure.