A systematic review of pharmacological pain management in multiple sclerosis

CRD SUMMARY:

This review concluded that anticonvulsants and off-label use of dextromethorphan/quinidine were identified as promising treatments for chronic pain in multiple sclerosis but that the evidence was insufficient to establish how to choose optimal therapy for particular patients. Limitations of the evidence and reporting in the review mean that the conclusions regarding anticonvulsants and dextromethorphan/quinidine may not be reliable; the part of the conclusion regarding optimal therapy appears appropriate because it reflects the paucity of the evidence presented.