CRD SUMMARY: This review compared the effect of B-type natriuretic peptide (BNP)-guided drug therapy with usual care in patients with chronic heart failure. The authors concluded that BNP-guided therapy reduced all-cause mortality, especially in patients younger than 75 years. This was a reasonably well-conducted review, but the uncertain quality of included trials and concerns regarding generalisability warrant some cautious interpretation.
This review compared the effect of B-type natriuretic peptide (BNP)-guided drug therapy with usual care in patients with chronic heart failure. The authors concluded that BNP-guided therapy reduced all-cause mortality, especially in patients younger than 75 years. This was a reasonably well-conducted review, but the uncertain quality of included trials and concerns regarding generalisability warrant some cautious interpretation.
