What is the risk of sham surgery in Parkinson disease clinical trials? A review of published reports.

Category Systematic review
JournalNeurology
Year 2005
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Placebo, or sham surgery, as a control condition in surgical clinical trials in Parkinson disease (PD) remains controversial. The authors reviewed the adverse effects reported in double blind, placebo surgery controlled trials for PD. Placebo surgeries were generally safe and well tolerated but the number of subjects receiving the procedure was small. Harm occurred more frequently in subjects randomized to the experimental intervention.
Epistemonikos ID: dd5fa1362ecffb18d9797458e3ca270a49d2ac60
First added on: Jan 19, 2012