A comparison between enriched and nonenriched enrollment randomized withdrawal trials of opioids for chronic noncancer pain

Category Structured summary of systematic reviews
JournalDatabase of Abstracts of Reviews of Effects (DARE)
Year 2012
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CRD SUMMARY:

This review concluded that enriched enrolment randomised withdrawal trials did not affect efficacy, but did underestimate adverse effects. Given the small proportion of enriched enrolment randomised withdrawal trials and that the comparisons of opioids with other drugs were based on trials that were not designed to be equivalence trials, the authors' conclusions should be interpreted with caution.
Epistemonikos ID: 945eb5b5d7c5ca1303f8e3aeff0007a961a961d3
First added on: Dec 17, 2012