Effect of red beetroot in subjects with pre-diabetes

INTERVENTION:

Intervention 1: Intervention group: Red beetroot powder prepared by Pak Shilan Negin Salamat private company located in Chaharmahal and Bakhtiari province, producing all kinds of fruit powder, summer vegetables, and dried vegetables, 7 grams twice a day (14 grams daily) for 12 weeks. (3 months), it is eaten with yogurt, salad, or a meal during lunch and dinner. Intervention 2: Control group: Rice powder prepared by Pak Shilan Negin Salamat private company located in Chaharmahal and Bakhtiari province, producing all kinds of fruit powder, summer vegetables, and dried vegetables, 7 grams twice a day (14 grams daily) for 12 weeks (3 months ), it is eaten with yogurt, salad, or a meal during lunch and dinner.

CONDITION:

Prediabetes. ; Impaired glucose tolerance (oral) R73.02

PRIMARY OUTCOME:

2‐hour blood glucose. Timepoint: At the baseline and after 12 weeks. Method of measurement: Enzyme calorimetry method. Fasting blood sugar. Timepoint: At the baseline and after 12 weeks. Method of measurement: Enzyme calorimetry method. Fasting insulin. Timepoint: At the baseline and after 12 weeks. Method of measurement: The enzyme‐linked immunosorbent assay. Hemoglobin A1C. Timepoint: At the baseline and after 12 weeks. Method of measurement: Enzyme calorimetry method. Homeostatic model assessment for insulin resistance. Timepoint: At the baseline and after 12 weeks. Method of measurement: Calculated by formula. The quantitative insulin‐sensitivity check index. Timepoint: At the baseline and after 12 weeks. Method of measurement: Calculated by formula.

INCLUSION CRITERIA:

Age 20‐80 years old BMI 18‐35 kg/m2

SECONDARY OUTCOME:

Alanine transaminase. Timepoint: At the baseline and after 12 weeks. Method of measurement: Enzyme calorimetry method. Alkaline Phosphatase. Timepoint: At the baseline and after 12 weeks. Method of measurement: Enzyme calorimetry method. Aspartate aminotransferase. Timepoint: At the baseline and after 12 weeks. Method of measurement: Enzyme calorimetry method. Blood urea nitrogen. Timepoint: At the baseline and after 12 weeks. Method of measurement: Enzyme calorimetry method. Gamma‐glutamyltransferase. Timepoint: At the baseline and after 12 weeks. Method of measurement: Enzyme calorimetry method. Glutathione. Timepoint: At the baseline and after 12 weeks. Method of measurement: The enzyme‐linked immunosorbent assay. High density lipoprotein. Timepoint: At the baseline and after 12 weeks. Method of measurement: Enzyme calorimetry method. High sensitivity‐C Reactive Protein. Timepoint: At the baseline and after 12 weeks. Method of measurement: The enzyme‐linked immunosorbent assay. Low density lipoprotein. Timepoint: At the baseline and after 12 weeks. Method of measurement: Enzyme calorimetry method. Serum creatinine. Timepoint: At the baseline and after 12 weeks. Method of measurement: Kinetic Jaffe calorimetry. The Fibrosis‐4 score. Timepoint: At the baseline and after 12 weeks. Method of measurement: Calculated by formula. Total antioxidant capacity. Timepoint: At the baseline and after 12 weeks. Method of measurement: The enzyme‐linked immunosorbent assay. Total cholesterol. Timepoint: At the baseline and after 12 weeks. Method of measurement: Enzyme calorimetry method. Total oxidative stress. Timepoint: At the baseline and after 12 weeks. Method of measurement: The enzyme‐linked immunosorbent assay. Triglyceride. Timepoint: At the baseline and after 12 weeks. Method of measurement: Enzyme calorimetry method. Urine creatinine. Timepoint: At the baseline and after 12 weeks. Method of measurement: Kinetic Jaffe calorimetry. Urine microalbumin. Timepoint: At the baseline and after 12 weeks. Method of measurement: The enzyme‐linked immunosorbent assay.