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Broad synthesis / Overview of systematic reviews

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Effective interventions for improving routine childhood immunisation in low and middle-income countries: a systematic review of systematic reviews.

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Journal BMJ open
Year 2024
Links Pubmed DOI PubMed Central

This article includes 42 Systematic reviews Systematic reviews (42 references)

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OBJECTIVE: An umbrella review providing a comprehensive synthesis of the interventions that are effective in providing routine immunisation outcomes for children in low and middle-income countries (L&MICs). DESIGN: A systematic review of systematic reviews, or an umbrella review. DATA SOURCES: We comprehensively searched 11 academic databases and 23 grey literature sources. The search was adopted from an evidence gap map on routine child immunisation sector in L&MICs, which was done on 5 May 2020. We updated the search in October 2021. ELIGIBILITY CRITERIA: We included systematic reviews assessing the effectiveness of any intervention on routine childhood immunisation outcomes in L&MICs. DATA EXTRACTION AND SYNTHESIS: Search results were screened by two reviewers independently applying predefined inclusion and exclusion criteria. Data were extracted by two researchers independently. The Specialist Unit for Review Evidence checklist was used to assess review quality. A mixed-methods synthesis was employed focusing on meta-analytical and narrative elements to accommodate both the quantitative and qualitative information available from the included reviews. RESULTS: 62 systematic reviews are included in this umbrella review. We find caregiver-oriented interventions have large positive and statistically significant effects, especially those focusing on short-term sensitisation and education campaigns as well as written messages to caregivers. For health system-oriented interventions the evidence base is thin and derived from narrative synthesis suggesting positive effects for home visits, mixed effects for pay-for-performance schemes and inconclusive effects for contracting out services to non-governmental providers. For all other interventions under this category, the evidence is either limited or not available. For community-oriented interventions, a recent high-quality mixed-methods review suggests positive but small effects. Overall, the evidence base is highly heterogenous in terms of scope, intervention types and outcomes. CONCLUSION: Interventions oriented towards caregivers and communities are effective in improving routine child immunisation outcomes. The evidence base on health system-oriented interventions is scant not allowing us to reach firm conclusions, except for home visits. Large evidence gaps exist and need to be addressed. For example, more high-quality evidence is needed for specific caregiver-oriented interventions (eg, monetary incentives) as well as health system-oriented (eg, health workers and data systems) and community-oriented interventions. We also need to better understand complementarity of different intervention types.

Broad synthesis / Overview of systematic reviews

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A meta-review demonstrates improved reporting quality of qualitative reviews following the publication of COREQ- and ENTREQ-checklists, regardless of modest uptake.

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Journal BMC medical research methodology
Year 2021
Links Pubmed DOI PubMed Central

This article includes 1608 Systematic reviews Systematic reviews (1608 references) 31 Primary studies Primary studies (31 references)

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BACKGROUND: Reviews of qualitative studies allow for deeper understanding of concepts and findings beyond the single qualitative studies. Concerns on study reporting quality led to the publication of the COREQ-guidelines for qualitative studies in 2007, followed by the ENTREQ-guidelines for qualitative reviews in 2012. The aim of this meta-review is to: 1) investigate the uptake of the COREQ- and ENTREQ- checklists in qualitative reviews; and 2) compare the quality of reporting of the primary qualitative studies included within these reviews prior- and post COREQ-publication. METHODS: Reviews were searched on 02-Sept-2020 and categorized as (1) COREQ- or (2) ENTREQ-using, (3) using both, or (4) non-COREQ/ENTREQ. Proportions of usage were calculated over time. COREQ-scores of the primary studies included in these reviews were compared prior- and post COREQ-publication using T-test with Bonferroni correction. RESULTS: 1.695 qualitative reviews were included (222 COREQ, 369 ENTREQ, 62 both COREQ/ENTREQ and 1.042 non-COREQ/ENTREQ), spanning 12 years (2007-2019) demonstrating an exponential publication rate. The uptake of the ENTREQ in reviews is higher than the COREQ (respectively 28% and 17%), and increases over time. COREQ-scores could be extracted from 139 reviews (including 2.775 appraisals). Reporting quality improved following the COREQ-publication with 13 of the 32 signalling questions showing improvement; the average total score increased from 15.15 to 17.74 (p-value < 0.001). CONCLUSION: The number of qualitative reviews increased exponentially, but the uptake of the COREQ and ENTREQ was modest overall. Primary qualitative studies show a positive trend in reporting quality, which may have been facilitated by the publication of the COREQ.

Broad synthesis / Overview of systematic reviews

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Strategies intended to address vaccine hesitancy: Review of published reviews.

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Journal Vaccine
Year 2015
Links Pubmed DOI

This article includes 12 Systematic reviews Systematic reviews (12 references)

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When faced with vaccine hesitancy, public health authorities are looking for effective strategies to address this issue. In this paper, the findings of 15 published literature reviews or meta-analysis that have examined the effectiveness of different interventions to reduce vaccine hesitancy and/or to enhance vaccine acceptance are presented and discussed. From the literature, there is no strong evidence to recommend any specific intervention to address vaccine hesitancy/refusal. The reviewed studies included interventions with diverse content and approaches that were implemented in different settings and targeted various populations. Few interventions were directly targeted to vaccine hesitant individuals. Given the paucity of information on effective strategies to address vaccine hesitancy, when interventions are implemented, planning a rigorous evaluation of their impact on vaccine hesitancy/vaccine acceptance will be essential.

Broad synthesis / Overview of systematic reviews

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Does ownership matter? An overview of systematic reviews of the performance of private for-profit, private not-for-profit and public healthcare providers

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Journal PLoS ONE
Year 2014
Links Pubmed DOI PubMed Central

This article includes 15 Systematic reviews Systematic reviews (15 references)

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INTRODUCTION: Ownership of healthcare providers has been considered as one factor that might influence their health and healthcare related performance. The aim of this article was to provide an overview of what is known about the effects on economic, administrative and health related outcomes of different types of ownership of healthcare providers--namely public, private non-for-profit (PNFP) and private for-profit (PFP)--based on the findings of systematic reviews (SR). METHODS AND FINDINGS: An overview of systematic reviews was performed. Different databases were searched in order to select SRs according to an explicit comprehensive criterion. Included SRs were assessed to determine their methodological quality. Of the 5918 references reviewed, fifteen SR were included, but six of them were rated as having major limitations, so they weren't incorporated in the analyses. According to the nine analyzed SR, ownership does seem to have an effect on health and healthcare related outcomes. In the comparison of PFP and PNFP providers, significant differences in terms of mortality of patients and payments to facilities have been found, both being higher in PFP facilities. In terms of quality and economic indicators such as efficiency, there are no concluding results. When comparing PNFP and public providers, as well as for PFP and public providers, no clear differences were found. CONCLUSION: PFP providers seem to have worst results than their PNFP counterparts, but there are still important evidence gaps in the literature that needs to be covered, including the comparison between public and both PFP and PNFP providers. More research is needed in low and middle income countries to understand the impact on and development of healthcare delivery systems.

Broad synthesis

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Evidence for integrating eye health into primary health care in Africa: a health systems strengthening approach.

Journal BMC health services research
Year 2013
Links Pubmed DOI PubMed Central

This article includes 109 Primary studies Primary studies (109 references) 23 Systematic reviews Systematic reviews (23 references)

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BACKGROUND: The impact of unmet eye care needs in sub-Saharan Africa is compounded by barriers to accessing eye care, limited engagement with communities, a shortage of appropriately skilled health personnel, and inadequate support from health systems. The renewed focus on primary health care has led to support for greater integration of eye health into national health systems. The aim of this paper is to demonstrate available evidence of integration of eye health into primary health care in sub-Saharan Africa from a health systems strengthening perspective. METHODS: A scoping review method was used to gather and assess information from published literature, reviews, WHO policy documents and examples of eye and health care interventions in sub-Saharan Africa. Findings were compiled using a health systems strengthening framework. RESULTS: Limited information is available about eye health from a health systems strengthening approach. Particular components of the health systems framework lacking evidence are service delivery, equipment and supplies, financing, leadership and governance. There is some information to support interventions to strengthen human resources at all levels, partnerships and community participation; but little evidence showing their successful application to improve quality of care and access to comprehensive eye health services at the primary health level, and referral to other levels for specialist eye care. CONCLUSION: Evidence of integration of eye health into primary health care is currently weak, particularly when applying a health systems framework. A realignment of eye health in the primary health care agenda will require context specific planning and a holistic approach, with careful attention to each of the health system components and to the public health system as a whole. Documentation and evaluation of existing projects are required, as are pilot projects of systematic approaches to interventions and application of best practices. Multi-national research may provide guidance about how to scale up eye health interventions that are integrated into primary health systems.

Broad synthesis

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More money for HRH: More HRH for the money

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Authors GHWA
Report GHWA
Year 2012
Links http://www.who.int/workforcealliance/knowledge/resources/hrhfinancingbrief2012/en/index.html

This article includes 1 Systematic review Systematic reviews (1 reference) 6 Primary studies Primary studies (6 references)

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Health costs are spiralling out of control all over the world in context of global financial crisis while some countries are still struggling to offer basic health services. The health sector in Sub-Saharan Africa is most often unfunded, including the health workforce, which represents the single largest item in health budgets. On the other hand, countries do not meet the minimum health staffing levels to provide essential care. Ministries of Finance and Health need to jointly identify and allocate additional financial resources - for HRH - to maximize the efficiency and effectiveness of current capital and recurrent expenditures.

Broad synthesis

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How to achieve universal coverage of cataract surgical services in developing countries: lessons from systematic reviews of other services.

Journal Ophthalmic epidemiology
Year 2012
Links Pubmed DOI

This article includes 18 Systematic reviews Systematic reviews (18 references)

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PURPOSE: Since the Declaration of Alma Ata, universal coverage has been at the heart of international health. The purpose of this study was to review the evidence on factors and interventions which are effective in promoting coverage and access to cataract and other health services, focusing on developing countries. METHODS: A thorough literature search for systematic reviews was conducted. Information resources searched were Medline, The Cochrane Library and the Health System Evidence database. Medline was searched from January 1950 to June 2010. The Cochrane Library search consisted of identifying all systematic reviews produced by the Cochrane Eyes and Vision Group and the Cochrane Effective Practice and Organisation of Care. These reviews were assessed for potential inclusion in the review. The Health Systems Evidence database hosted by MacMaster University was searched to identify overviews of systematic reviews. RESULTS: No reviews met the inclusion criteria for cataract surgery. The literature search on other health sectors identified 23 systematic reviews providing robust evidence on the main factors facilitating universal coverage. The main enabling factors influencing access to services in developing countries were peer education, the deployment of staff to rural areas, task shifting, integration of services, supervision of health staff, eliminating user fees and scaling up of health insurance schemes. CONCLUSION: There are significant research gaps in eye care. There is a pressing need for further high quality primary research on health systems-related factors to understand how the delivery of eye care services and health systems' capacities are interrelated.

Broad synthesis / Scoping review

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Social franchising evaluations: A scoping review

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Report London: EPPI-Centre, Social Science Research Unit, Institute of Education, University of London.
Year 2011
Links 3ie Systematic Reviews EppiCentre Fulltext link

This article includes 7 Primary studies Primary studies (7 references) 3 Systematic reviews Systematic reviews (3 references)

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BACKGROUND: Social franchising developed as a possible means of improving the provision of non-state sector health services in low- and middle-income countries. The objective of this systematic review was to examine the scope and nature of existing research literature on social franchising interventions, including reach, implementation, sustainability and goals, in health service delivery. METHODS: A rigorous search strategy was run in nine major databases, including Medline, Embase and CINAHL. Grey literature was also searched. All types of evaluative study designs were eligible for inclusion. Existing data abstraction and analysis tools were used. The AMSTAR measurement tool was applied to assess the quality of included systematic reviews. Framework analysis was chosen for synthesising qualitative and quantitative research. RESULTS: Twelve studies were included in this review: three systematic reviews and nine primary studies. Social franchising has been evaluated in Asia and Africa, particularly from lowincome countries. Most studies focused on reproductive health and family planning. We found a paucity of rigorous study designs, so the evidence supporting social franchising is weak. Across settings, the government continues to have the highest volume of clients for family planning and other services; however, franchises do better than non-franchised private providers in terms of client volume. The clients of social franchises are satisfied with the quality of care and consistently report an intent to return. CONCLUSIONS: Given that social franchising remains an area of great interest and investment, we recommend evaluations of implementation processes and sustainability, and more rigorous evaluations of the effects of different models.

Broad synthesis / Policy brief

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Policy brief on improving access to artemisinin-based combination therapies for malaria in Cameroon.

Journal International journal of technology assessment in health care
Year 2010
Links Pubmed DOI

This article includes 4 Primary studies Primary studies (4 references) 2 Systematic reviews Systematic reviews (2 references)

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