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Broad synthesis / Guideline

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Guidance for the use of medicinal cannabis for the prevention or management of nausea and vomiting in Australia

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Journal Therapeutic Goods Administration (TGA)
Year 2017
Links tga.gov.au
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This document reflects the evidence supporting the use of medicinal cannabis in nausea and vomiting and the recommendations of the Nausea and Vomiting Working Group

Broad synthesis / Living FRISBEE

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Are cannabinoids effective for HIV wasting syndrome?

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Authors Núñez A , Núñez C , Corsi O , Rada G
Journal Medwave
Year 2017
Links Pubmed DOI
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INTRODUCTION: Wasting syndrome is a common problem in HIV. It leads to substantive morbidity and mortality. The use of cannabinoids has been suggested as a treatment for weight, but it is not clear whether they are really safe and effective. METHODS: To answer this question we used Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data of primary studies and generated a summary of findings table using the GRADE approach. RESULTS AND CONCLUSIONS: We identified eight systematic reviews including ten studies overall, of which six were randomized trials. We concluded it is not clear whether cannabinoids increase appetite or weight in HIV wasting syndrome because the certainty of the evidence is very low, and they probably lead to frequent adverse effects.

Broad synthesis / Living FRISBEE

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Are cannabinoids an effective treatment for chronic non-cancer pain?

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Authors Allende-Salazar RF , Rada G
Journal Medwave
Year 2017
Links Pubmed DOI
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The use of cannabinoids has been proposed as an analgesic for different painful conditions, especially for chronic pain refractory to usual treatment. However, its real efficacy and safety remains controversial. We sought to determine whether cannabinoids are an effective treatment for chronic non-cancer pain. To answer this question, we used Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We identified 37 systematic reviews including 41 studies overall, of which 32 were randomized trials relevant for the question of interest. We extracted data from the systematic reviews, reanalyzed data of primary studies, conducted a meta-analysis and generated a summary of findings table using the GRADE approach. We concluded it is not clear whether cannabinoids decrease pain in patients with chronic non-cancer pain because the certainty of available evidence is very low. On the other hand, they are associated with significant adverse effects.

Broad synthesis / Living FRISBEE

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Are cannabinoids effective for the management of chemotherapy induced nausea and vomiting?

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Authors Morales M , Corsi O , Peña J
Journal Medwave
Year 2017
Links Pubmed DOI
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INTRODUCTION: Nausea and vomiting are common side effects in cancer patients treated with chemotherapy. Proper control of these symptoms might improve quality of life in these patients. Addition of cannabinoids to standard antiemetic treatment has been proposed in order to improve control of these symptoms. METHODS: To answer this question we used Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data of primary studies, conducted a meta-analysis and generated a summary of findings table using the GRADE approach. RESULTS AND CONCLUSIONS: We identified 16 systematic reviews that include 61 primary studies. Out of these, four were randomized trials that answered our question. At present, given that the certainty of the evidence is very low, it is unclear whether the addition of cannabinoids to standard antiemetic regimes benefits patients with chemotherapy induced nausea and vomiting. Cannabinoids probably increase adverse effects substantively.

Broad synthesis / Living FRISBEE

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Are cannabinoids an alternative for cachexia-anorexia syndrome in patients with advanced cancer?

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Authors Cabeza C , Corsi O , Pérez-Cruz P
Journal Medwave
Year 2017
Links Pubmed DOI
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INTRODUCTION: Cachexia and anorexia are among the most frequent symptoms in patients with cancer. Cannabinoids have been used in patients with advanced cancer; however, their role is still controversial. METHODS: To answer this question we used Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data of primary studies, and generated a summary of findings table using the GRADE approach. RESULTS AND CONCLUSIONS: We identified ten systematic reviews including three studies overall, of which two were randomized trials. We concluded it is not clear whether cannabinoids have any positive effect on increasing weight because the certainty of the evidence is very low. They might not have any effect on appetite, and are probably associated to frequent adverse effects.

Broad synthesis / Living FRISBEE

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Are cannabinoids effective in multiple sclerosis?

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Authors Meza R , Peña J , García K , Corsi O , Rada G
Journal Medwave
Year 2017
Links Pubmed DOI
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Multiple beneficial effects have been proposed lately for cannabinoids in different clinical situations. Among them, it has been postulated they would control symptoms of multiple sclerosis. However, there is no consensus about their real clinical role. To answer this question, we searched in Epistemonikos database, which is maintained by screening multiple databases. We identified 25 systematic reviews including 35 studies overall, of which 26 were randomized trials. We extracted data, conducted a meta-analysis and generated a summary of findings table using the GRADE approach. We concluded cannabinoids in multiple sclerosis do not reduce spasticity or pain, and are probably associated to frequent adverse effects.

Broad synthesis / Guideline

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Guidance for the use of medicinal cannabis in the treatment of multiple sclerosis in Australia

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Journal Therapeutic Goods Administration (TGA)
Year 2017
Links tga
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This document reflects the evidence supporting the use of medicinal cannabis in treating symptoms of MS

Broad synthesis / Living FRISBEE

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Are cannabinoids effective for epilepsy?

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Authors Peña J , Rada G
Journal Medwave
Year 2017
Links Pubmed DOI
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Several beneficial effects have been proposed for cannabinoids in different clinical conditions, including epilepsy. However, their clinical role is controversial. Searching in Epistemonikos database, which is maintained by screening multiple databases, we identified five systematic reviews including four randomized trials addressing the question of this article. We extracted data and generated a summary of findings following the GRADE approach. We concluded it is not clear whether cannabinoids reduce the frequency of seizures in epilepsy because the certainty of the evidence is very low, and they probably increase adverse effects.

Broad synthesis / Guideline

Unclassified

Guidance for the use of medicinal cannabis in the treatment of palliative care patients in Australia

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Journal Therapeutic Goods Administration (TGA)
Year 2017
Links tga.gov.au
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This document reflects the evidence supporting the use of medicinal cannabis in palliative care patients and the recommendations of the Palliative Care Working Group

Broad synthesis / Guideline

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The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research

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Journal Washington, DC: The National Academies Press
Year 2017
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