Primary studies included in this systematic review

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Effect of a reminder system using an automated short message service on medication adherence following acute coronary syndrome.

Journal European journal of cardiovascular nursing : journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology
Year 2015
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Cet article est inclus dans 7 Systematic reviews Systematic reviews (7 references)

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BACKGROUND: Medication non-adherence leads to a vast range of negative outcomes in patients with coronary artery disease. An automated web-based system managing short message service (SMS) reminders is a telemedicine approach to optimise adherence among patients who frequently forget to take their medications or miss the timing. AIM: This paper sought to investigate the effect of automated SMS-based reminders on medication adherence in patients after hospital discharge following acute coronary syndrome (ACS). METHODS: An interventional study was conducted at a tertiary teaching hospital in Malaysia. A total of 62 patients with ACS were equally randomised to receive either automated SMS reminders before every intake of cardiac medications or only usual care within eight weeks after discharge. The primary outcome was adherence to cardiac medications. Secondary outcomes were the heart functional status, and ACS-related hospital readmission and death rates. RESULTS: There was a higher medication adherence level in the intervention group rather than the usual care group, (χ(2) (2)=18.614, p<0.001). The risk of being low adherent among the control group was 4.09 times greater than the intervention group (relative risk =4.09, 95% confidence interval (CI) 1.82-9.18). A meaningful difference was found in heart functional status between the two study groups with better results among patients who received SMS reminders, (χ(2) (1) = 16.957, p<0.001). CONCLUSION: An automated SMS-based reminder system can potentially enhance medication adherence in ACS patients during the early post-discharge period.

Primary study

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A text messaging intervention to promote medication adherence for patients with coronary heart disease: A randomized controlled trial.

Journal Patient education and counseling
Year 2014
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Cet article est inclus dans 10 Systematic reviews Systematic reviews (10 references)

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OBJECTIVE: Pharmacologic treatment for secondary prevention of coronary heart disease (CHD) is critical to prevent adverse clinical outcomes. In a randomized controlled trial, we compared antiplatelet and statin adherence among patients with CHD who received: (1) text messages (TM) for medication reminders and education, (2) educational TM only, or (3) No TM. METHODS: A mobile health intervention delivered customized TM for 30 days. We assessed and analyzed medication adherence with electronic monitoring devices [Medication Event Monitoring System (MEMS)] by one-way ANOVA and Welch tests, two-way TM response rates by t-tests, and self-reported adherence (Morisky Medication Adherence Scale) by Repeated Measures ANOVA. RESULTS: Among 90 patients (76% male, mean age 59.2 years), MEMS revealed patients who received TM for antiplatelets had a higher percentage of correct doses taken (<i>p</i> = 0.02), percentage number of doses taken (<i>p</i> = 0.01), and percentage of prescribed doses taken on schedule (<i>p</i> = 0.01). TM response rates were higher for antiplatelets than statins (<i>p</i> = 0.005). Self-reported adherence revealed no significant differences among groups. CONCLUSION: TM increased adherence to antiplatelet therapy demonstrated by MEMS and TM responses. Practice implications: Feasibility and high satisfaction were established. Mobile health interventions show promise in promoting medication adherence. (PsycInfo Database Record (c) 2021 APA, all rights reserved)

Primary study

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Randomised trial of text messaging on adherence to cardiovascular preventive treatment (INTERACT Trial)

Journal PloS one
Year 2014
Liens Pubmed DOI PubMed Central

Cet article est inclus dans 7 Systematic reviews Systematic reviews (7 references)

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Background: About one third of patients prescribed blood pressure or lipidlowering drugs for the prevention of coronary heart disease and stroke do not take their medication as prescribed. We conducted a randomized trial to evaluate text messaging as a means of improving adherence to cardiovascular disease preventive treatment.; Methods: 303 patients taking blood pressure and/or lipid-lowering medications were randomly assigned to being sent text messages (Text group, 151) or not being sent them (No text group, 152). Texts were sent daily for 2 weeks, alternate days for 2 weeks and weekly thereafter for 22 weeks (6 months overall), using an automated computer programme. Patients were asked to respond on whether they had taken their medication, whether the text reminded them to do so if they had forgotten, and if they had not taken their medication to determine if there was a reason for not doing so. At 6 months, use of medication was assessed.; Results: Two patients were lost to follow-up, providing data on 301 for analysis. In the No text group 38/151 (25%) took less than 80% of the prescribed regimen (ie. stopped medication completely or took it on fewer than 22 of the last 28 days of follow-up) compared to 14/150 patients (9%) in the Text group - An improvement in adherence affecting 16 per 100 patients (95% CI 7 to 24), p>0.001. The texts reminded 98/151 patients (65%) to take medication on at least one occasion and lead to 20/151 (13%) who stopped taking medication because of concern over efficacy or side-effects, resuming treatment. © 2014 Wald et al.

Primary study

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A randomized controlled trial to assess adherence to allergic rhinitis treatment following a daily short message service (SMS) via the mobile phone

Auteurs Wang K , Wang C , Xi L , Zhang Y , Ouyang Y , Lou H , Zhang W , Zhang L
Journal International archives of allergy and immunology
Year 2014
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Cet article est inclus dans 5 Systematic reviews Systematic reviews (5 references)

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Background: Short message service (SMS) has been suggested as an effective method to improve adherence to medical therapy in some chronic diseases. However, data on the effects of SMS interventions to allergic rhinitis (AR) treatment is limited at present. We aimed to assess whether a daily SMS reminder could improve AR patients' adherence to medication and treatment outcomes. Methods: Fifty outpatients with AR were randomized to either receive (SMS group) or not (control group) a daily SMS reminder on their cell phone to take intranasal corticosteroid treatment for 30 days. The primary study outcomes were self-reported adherence to medication, clinic attendance rate, and severity of AR symptoms using a visual analogue scale (VAS). Secondary outcomes were changes in nasal patency (minimum cross-sectional area, nasal cavity volume, and nasal airway resistance) and exhaled nasal nitric oxide levels. Results: Self-reported adherence to medication in the SMS group (15/25, 60%), was significantly higher than in the control group (7/25, 28%, p = 0.02). Similarly, the clinic attendance rate in the SMS group (72%) was significantly higher than in the control group (40%, p = 0.02). Although the VAS score improved significantly from baseline in both study groups, the improvement in the SMS group was significantly greater than in the control group (4.38 ± 4.38 vs. 8.74 ± 6.54, p = 0.031). No significant differences were observed between the two groups for the secondary outcomes. Conclusions: A daily SMS reminder may be an effective intervention to improve adherence to medication and treatment outcomes in AR patients. © 2013 S. Karger AG, Basel.

Primary study

Unclassified

Effect of motivational mobile phone short message service on aspirin adherence after coronary stenting for acute coronary syndrome.

Journal International journal of cardiology
Year 2013
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Cet article est inclus dans 5 Systematic reviews Systematic reviews (5 references)

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A randomised controlled trial of an sms-based mobile epilepsy education system

Auteurs Lua PL , Neni WS
Journal Journal of telemedicine and telecare
Year 2013
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Cet article est inclus dans 2 Systematic reviews Systematic reviews (2 references)

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We evaluated an epilepsy education programme based on text messaging (SMS). Epilepsy outpatients from three hospitals in Malaysia were randomised into two groups: intervention and control. Patients in the control group were supplied with printed epilepsy educational material while those in the intervention group also received text messages from the Mobile Epilepsy Educational System (MEES). A total of 136 patients completed the study (mean age 31 years; 91% Malay; 51% with an illness duration of more than 5 years). A between-group analysis showed that the awareness, knowledge and attitudes (AKA) about epilepsy did not significantly differ between the groups at baseline(P > 0.05). The intervention patients reported better AKA levels during follow-up compared to the control patients (P < 0.05). A within-group analysis showed that in intervention patients, there were significant improvements in all AKA domains with larger effect sizes (P < 0.01) while control patients also exhibited significant improvement in most domains except for Awareness but with smaller effect sizes. After controlling for possible confounding variables (age, gender, educational qualification, monthly income and baseline mean for each domain), the intervention group still reported significantly higher AKA than the control group particularly in Awareness (P < 0.001) and Total AKA (P = 0.003). There was also significantly better medication adherence and clinic attendance in the intervention group (P < 0.05). The results suggest that the addition of the MEES to conventional epilepsy education is effective in improving AKA.

Primary study

Unclassified

Adherence counseling and reminder text messages improve uptake of antiretroviral therapy in a tertiary hospital in Nigeria.

Auteurs Maduka O , Tobin-West CI
Journal Nigerian journal of clinical practice
Year 2013
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Cet article est inclus dans 5 Systematic reviews Systematic reviews (5 references)

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CONTEXT: Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) is one of the world's most challenging pandemics. For treatment with Highly Active Anti-Retroviral Therapy (HAART) to be effective, high rate of adherence is essential. AIM: To demonstrate the effect of adherence counseling and text message reminders in improving patients' adherence to HAART. SETTINGS AND DESIGN: A randomized control trial among non-adherents was carried out in a tertiary hospital in Nigeria between March and July, 2011. MATERIALS AND METHODS: A total of 104 patients: 45 males (43.3%) and 59 females (56.7%) participated in the study. They were randomized into intervention and control groups. The intervention group received monthly adherence counseling and twice weekly short message reminders for four months, while the control group received only standard care. Self-reported adherence and CD4+ cell counts were measured pre- and post-intervention. STATISTICAL ANALYSIS USED: Data was analysed using Statistical Package for Social Sciences (SPSS) version 18. Risk rates, Chi-square, Mann-Whitney U test and Cohen's effect size were calculated. Level of significance was set at P = 0.05. RESULTS: At post-intervention, 76.9% of the intervention group and 55.8% of the control group achieved adherence (χ2 = 5.211, P = 0.022, RR = 0.75 (0.55-0.96), Cohen's w = 0.224). Also, median CD4+ cell count of the intervention group increased from 193 cells/ml to 575.0 cells/ml against 131.0 cells/ml to 361.5 cells/ml in the control group (P = 0.007). CONCLUSION: Adherence counseling and text message reminders improved adherence among HIV patients. Its adoption for HIV patient management is advocated.

Primary study

Unclassified

Le téléphone mobile SMS Cameroun (CAMPS) d'essai: un essai randomisé de la messagerie texte par rapport aux soins habituels pour l'adhésion à la thérapie antirétrovirale.

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Journal PloS one
Year 2012
Liens Pubmed DOI PubMed Central

Cet article est inclus dans 12 Systematic reviews Systematic reviews (12 references)

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CONTEXTE: la technologie de téléphonie mobile est une nouvelle façon de fournir des soins de santé et améliorer les résultats de santé. Cet essai étudie l'utilisation de la motivation de téléphonie mobile des messages texte (SMS) à améliorer l'observance au traitement antirétroviral (ARV) plus de six mois. METHODOLOGIE / PRINCIPAUX RÉSULTATS: CAMPS était un site unique randomisés à deux bras procès de conception parallèle à Yaoundé, Cameroun. Nous avons recruté et randomisé adultes séropositifs sous ARV, âgés de 21 ans et au-dessus de recevoir un message texte hebdomadaire normalisé de motivation comparativement aux soins habituels seuls. Le critère principal était l'adhésion mesurée en utilisant une échelle visuelle analogique (EVA), le nombre de doses manqué (dans la semaine précédant l'interview) et les données pharmacie de recharge. Les résultats ont été évalués à 3 et 6 mois. Les fournisseurs de services et les évaluateurs des résultats ont été aveuglés à l'allocation. L'analyse était en intention de traiter. Entre Novembre et Décembre 2010, 200 participants ont été randomisés, avec 101 dans le groupe d'intervention et 99 dans le groupe témoin. A 6 mois, la rétention globale était de 81,5%. Nous avons trouvé aucun effet significatif sur le respect par EVA> 95% (rapport de risque [RR] 1,06, 95% intervalle de confiance [IC] à 0,89, 1,29, p = 0,542; signalé doses manquées (RR 1,01, IC à 95% 0,87, 1,16; p > 0,999) ou le nombre de recharges de pharmacie (différence moyenne [MD] 0,1, IC 95%: 0,23, 0,43, p = 0,617. Un participant à bras d'intervention a enregistré une possible divulgation de la séropositivité. CONCLUSIONS / PORTÉE: normalisés téléphonie mobile de motivation des messages texte ne s'est pas améliorée de manière significative l'observance du traitement dans cette étude. D'autres types de messagerie ou études à long terme sont recommandés. INSCRIPTION: 1. Registre des essais cliniques panafricain; PACTR201011000261458 2. Clinicaltrials.gov; NCT01247181.

Primary study

Unclassified

Results of a randomized controlled trial to assess the effects of a mobile SMS-based intervention on treatment adherence in HIV/AIDS-infected Brazilian women and impressions and satisfaction with respect to incoming messages.

Journal International journal of medical informatics
Year 2012
Liens Pubmed DOI PubMed Central

Cet article est inclus dans 14 Systematic reviews Systematic reviews (14 references)

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<b>OBJECTIVE: </b>To assess whether a warning system based on mobile SMS messages increases the adherence of HIV-infected Brazilian women to antiretroviral drug-based treatment regimens and their impressions and satisfaction with respect to incoming messages.<b>DESIGN: </b>A randomized controlled trial was conducted from May 2009 to April 2010 with HIV-infected Brazilian women. All participants (n=21) had a monthly multidisciplinary attendance; each participant was followed over a 4-month period, when adherence measures were obtained. Participants in the intervention group (n=8) received SMS messages 30 min before their last scheduled time for a dose of medicine during the day. The messages were sent every Saturday and Sunday and on alternate days during the working week. Participants in the control group (n=13) did not receive messages.<b>Measurements: </b>Self-reported adherence, pill counting, microelectronic monitors (MEMS) and an interview about the impressions and satisfaction with respect to incoming messages.<b>RESULTS: </b>The HIV Alert System (HIVAS) was developed over 7 months during 2008 and 2009. After the study period, self-reported adherence indicated that 11 participants (84.62%) remained compliant in the control group (adherence exceeding 95%), whereas all 8 participants in the intervention group (100.00%) remained compliant. In contrast, the counting pills method indicated that the number of compliant participants was 5 (38.46%) for the control group and 4 (50.00%) for the intervention group. Microelectronic monitoring indicated that 6 participants in the control group (46.15%) were adherent during the entire 4-month period compared to 6 participants in the intervention group (75.00%). According to the feedback of the 8 participants who completed the research in the intervention group, along with the feedback of 3 patients who received SMS for less than 4 months, that is, did not complete the study, 9 (81.81%) believed that the SMS messages aided them in treatment adherence, and 10 (90.90%) responded that they would like to continue receiving SMS messages.<b>CONCLUSION: </b>SMS messaging can help Brazilian women living with HIV/AIDS to adhere to antiretroviral therapy for a period of at least 4 months. In general, the results are encouraging because the SMS messages stimulated more participants in the intervention group to be adherent to their treatment, and the patients were satisfied with the messages received, which were seen as reminders, incentives and signs of affection by the health clinic for a marginalized population.

Primary study

Unclassified

SMS reminders improve adherence to oral medication in type 2 diabetes patients who are real time electronically monitored.

Journal International journal of medical informatics
Year 2012
Liens Pubmed DOI

Cet article est inclus dans 12 Systematic reviews Systematic reviews (12 references)

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BACKGROUND: Poor adherence to oral antidiabetics has a negative influence on glycaemic control in type 2 diabetes patients. Real Time Medication Monitoring (RTMM) combines real time monitoring of patients' medication use with SMS reminders sent only if patients forget their medication, aiming to improve adherence. This study aimed to investigate the effect of these SMS reminders on adherence to oral antidiabetics in patients using RTMM and investigate patients' experiences with RTMM. METHODS: Data were collected in a RCT involving 104 type 2 diabetes patients with suboptimal adherence to oral antidiabetics. Fifty-six patients were randomised to receive SMS reminders if they forgot their medication, 48 patients received no reminders. Primary outcome measure was adherence to oral antidiabetics registered with RTMM, measured as: (1) days without dosing; (2) missed doses; (3) doses taken within predefined standardized time windows. Patients' experiences were assessed with written questionnaires. RESULTS: Over the six-month study period, patients receiving SMS reminders took significantly more doses within predefined time windows than patients receiving no reminders: 50% vs. 39% within a 1-h window (p=0.003) up to 81% vs. 70% within a 4-h window (p=0.007). Reminded patients tended to miss doses less frequently than patients not reminded (15% vs. 19%, p=0.065). Days without dosing were not significantly different between the groups. The majority of patients reported positive experiences with RTMM and SMS reminders. CONCLUSION: RTMM with SMS reminders improves adherence of type 2 diabetes patients, especially the precision with which patients follow their prescribed regimen, and is well accepted by patients. TRIAL REGISTRATION: Netherlands Trial Register NTR1882.