Primary studies included in this systematic review

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A text messaging intervention to promote medication adherence for patients with coronary heart disease: A randomized controlled trial.

Journal Patient education and counseling
Year 2014
Liens Pubmed DOI

Cet article est inclus dans 10 Systematic reviews Systematic reviews (10 references)

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OBJECTIVE: Pharmacologic treatment for secondary prevention of coronary heart disease (CHD) is critical to prevent adverse clinical outcomes. In a randomized controlled trial, we compared antiplatelet and statin adherence among patients with CHD who received: (1) text messages (TM) for medication reminders and education, (2) educational TM only, or (3) No TM. METHODS: A mobile health intervention delivered customized TM for 30 days. We assessed and analyzed medication adherence with electronic monitoring devices [Medication Event Monitoring System (MEMS)] by one-way ANOVA and Welch tests, two-way TM response rates by t-tests, and self-reported adherence (Morisky Medication Adherence Scale) by Repeated Measures ANOVA. RESULTS: Among 90 patients (76% male, mean age 59.2 years), MEMS revealed patients who received TM for antiplatelets had a higher percentage of correct doses taken (<i>p</i> = 0.02), percentage number of doses taken (<i>p</i> = 0.01), and percentage of prescribed doses taken on schedule (<i>p</i> = 0.01). TM response rates were higher for antiplatelets than statins (<i>p</i> = 0.005). Self-reported adherence revealed no significant differences among groups. CONCLUSION: TM increased adherence to antiplatelet therapy demonstrated by MEMS and TM responses. Practice implications: Feasibility and high satisfaction were established. Mobile health interventions show promise in promoting medication adherence. (PsycInfo Database Record (c) 2021 APA, all rights reserved)

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A randomized controlled trial to assess adherence to allergic rhinitis treatment following a daily short message service (SMS) via the mobile phone

Auteurs Wang K , Wang C , Xi L , Zhang Y , Ouyang Y , Lou H , Zhang W , Zhang L
Journal International archives of allergy and immunology
Year 2014
Liens Pubmed DOI

Cet article est inclus dans 5 Systematic reviews Systematic reviews (5 references)

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Background: Short message service (SMS) has been suggested as an effective method to improve adherence to medical therapy in some chronic diseases. However, data on the effects of SMS interventions to allergic rhinitis (AR) treatment is limited at present. We aimed to assess whether a daily SMS reminder could improve AR patients' adherence to medication and treatment outcomes. Methods: Fifty outpatients with AR were randomized to either receive (SMS group) or not (control group) a daily SMS reminder on their cell phone to take intranasal corticosteroid treatment for 30 days. The primary study outcomes were self-reported adherence to medication, clinic attendance rate, and severity of AR symptoms using a visual analogue scale (VAS). Secondary outcomes were changes in nasal patency (minimum cross-sectional area, nasal cavity volume, and nasal airway resistance) and exhaled nasal nitric oxide levels. Results: Self-reported adherence to medication in the SMS group (15/25, 60%), was significantly higher than in the control group (7/25, 28%, p = 0.02). Similarly, the clinic attendance rate in the SMS group (72%) was significantly higher than in the control group (40%, p = 0.02). Although the VAS score improved significantly from baseline in both study groups, the improvement in the SMS group was significantly greater than in the control group (4.38 ± 4.38 vs. 8.74 ± 6.54, p = 0.031). No significant differences were observed between the two groups for the secondary outcomes. Conclusions: A daily SMS reminder may be an effective intervention to improve adherence to medication and treatment outcomes in AR patients. © 2013 S. Karger AG, Basel.

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Does the use of an electronic reminder device with or without counseling improve adherence to lipid-lowering treatment? The results of a randomized controlled trial

Journal Frontiers in pharmacology
Year 2013
Liens Pubmed DOI PubMed Central

Cet article est inclus dans 3 Systematic reviews Systematic reviews (3 references)

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Background: Lipid-lowering treatment with statins has proven to be effective in reducing cardiovascular events and mortality. In daily practice, however, adherence to medication is often low and this compromises the therapeutic effect. The aim of this study was to assess the effectiveness of an electronic reminder device (ERD) with or without counseling to improve refill adherence and persistence for statin treatment in non-adherent patients. Methods: A multicenter, community pharmacy-based, randomized controlled trial was conducted in 24 pharmacies in the Netherlands among patients with pre-baseline refill adherence rates between 50 and 80%. Eligible patients aged 65 years or older were randomly assigned to 1 of 3 groups: (1) counseling with an ERD (n = 134), (2) ERD with a written instruction (n = 131), and a (3) control group that received the usual treatment (n = 134). Main outcome measure: refill adherence to statin treatment for a 360-day period after inclusion (PDC360). Patients with a refill rate ≥80% were considered adherent. The effect among subgroups was also assessed. Results: There were no relevant differences at baseline. In the counseling with ERD group 54 of 130 eligible patients received the counseling with ERD. In the ERD group, 117 of 123 eligible patients received the ERD. The proportions of adherent patients in the counseling with ERD-group (69.2%) and in the ERD group (72.4%) were not higher than in the control group (64.8%). Among women using statins for secondary prevention, more patients were adherent in the ERD group (86.1%) than in the control group (52.6%) (p < 0.005). In men using statins for secondary prevention the ERD was found to have no effect. Conclusion: In this randomized controlled trial, no statistically significant improvement of refill adherence was found if an ERD was used with or without counseling. However, in a subgroup of women using statins for secondary prevention the ERD did improve adherence significantly. © 2013 Kooy, van Wijk, Heerdink, de Boer and Bouvy.

Primary study

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Le téléphone mobile SMS Cameroun (CAMPS) d'essai: un essai randomisé de la messagerie texte par rapport aux soins habituels pour l'adhésion à la thérapie antirétrovirale.

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Journal PloS one
Year 2012
Liens Pubmed DOI PubMed Central

Cet article est inclus dans 12 Systematic reviews Systematic reviews (12 references)

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CONTEXTE: la technologie de téléphonie mobile est une nouvelle façon de fournir des soins de santé et améliorer les résultats de santé. Cet essai étudie l'utilisation de la motivation de téléphonie mobile des messages texte (SMS) à améliorer l'observance au traitement antirétroviral (ARV) plus de six mois. METHODOLOGIE / PRINCIPAUX RÉSULTATS: CAMPS était un site unique randomisés à deux bras procès de conception parallèle à Yaoundé, Cameroun. Nous avons recruté et randomisé adultes séropositifs sous ARV, âgés de 21 ans et au-dessus de recevoir un message texte hebdomadaire normalisé de motivation comparativement aux soins habituels seuls. Le critère principal était l'adhésion mesurée en utilisant une échelle visuelle analogique (EVA), le nombre de doses manqué (dans la semaine précédant l'interview) et les données pharmacie de recharge. Les résultats ont été évalués à 3 et 6 mois. Les fournisseurs de services et les évaluateurs des résultats ont été aveuglés à l'allocation. L'analyse était en intention de traiter. Entre Novembre et Décembre 2010, 200 participants ont été randomisés, avec 101 dans le groupe d'intervention et 99 dans le groupe témoin. A 6 mois, la rétention globale était de 81,5%. Nous avons trouvé aucun effet significatif sur le respect par EVA> 95% (rapport de risque [RR] 1,06, 95% intervalle de confiance [IC] à 0,89, 1,29, p = 0,542; signalé doses manquées (RR 1,01, IC à 95% 0,87, 1,16; p > 0,999) ou le nombre de recharges de pharmacie (différence moyenne [MD] 0,1, IC 95%: 0,23, 0,43, p = 0,617. Un participant à bras d'intervention a enregistré une possible divulgation de la séropositivité. CONCLUSIONS / PORTÉE: normalisés téléphonie mobile de motivation des messages texte ne s'est pas améliorée de manière significative l'observance du traitement dans cette étude. D'autres types de messagerie ou études à long terme sont recommandés. INSCRIPTION: 1. Registre des essais cliniques panafricain; PACTR201011000261458 2. Clinicaltrials.gov; NCT01247181.

Primary study

Unclassified

Results of a randomized controlled trial to assess the effects of a mobile SMS-based intervention on treatment adherence in HIV/AIDS-infected Brazilian women and impressions and satisfaction with respect to incoming messages.

Journal International journal of medical informatics
Year 2012
Liens Pubmed DOI PubMed Central

Cet article est inclus dans 14 Systematic reviews Systematic reviews (14 references)

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<b>OBJECTIVE: </b>To assess whether a warning system based on mobile SMS messages increases the adherence of HIV-infected Brazilian women to antiretroviral drug-based treatment regimens and their impressions and satisfaction with respect to incoming messages.<b>DESIGN: </b>A randomized controlled trial was conducted from May 2009 to April 2010 with HIV-infected Brazilian women. All participants (n=21) had a monthly multidisciplinary attendance; each participant was followed over a 4-month period, when adherence measures were obtained. Participants in the intervention group (n=8) received SMS messages 30 min before their last scheduled time for a dose of medicine during the day. The messages were sent every Saturday and Sunday and on alternate days during the working week. Participants in the control group (n=13) did not receive messages.<b>Measurements: </b>Self-reported adherence, pill counting, microelectronic monitors (MEMS) and an interview about the impressions and satisfaction with respect to incoming messages.<b>RESULTS: </b>The HIV Alert System (HIVAS) was developed over 7 months during 2008 and 2009. After the study period, self-reported adherence indicated that 11 participants (84.62%) remained compliant in the control group (adherence exceeding 95%), whereas all 8 participants in the intervention group (100.00%) remained compliant. In contrast, the counting pills method indicated that the number of compliant participants was 5 (38.46%) for the control group and 4 (50.00%) for the intervention group. Microelectronic monitoring indicated that 6 participants in the control group (46.15%) were adherent during the entire 4-month period compared to 6 participants in the intervention group (75.00%). According to the feedback of the 8 participants who completed the research in the intervention group, along with the feedback of 3 patients who received SMS for less than 4 months, that is, did not complete the study, 9 (81.81%) believed that the SMS messages aided them in treatment adherence, and 10 (90.90%) responded that they would like to continue receiving SMS messages.<b>CONCLUSION: </b>SMS messaging can help Brazilian women living with HIV/AIDS to adhere to antiretroviral therapy for a period of at least 4 months. In general, the results are encouraging because the SMS messages stimulated more participants in the intervention group to be adherent to their treatment, and the patients were satisfied with the messages received, which were seen as reminders, incentives and signs of affection by the health clinic for a marginalized population.

Primary study

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SMS reminders improve adherence to oral medication in type 2 diabetes patients who are real time electronically monitored.

Journal International journal of medical informatics
Year 2012
Liens Pubmed DOI

Cet article est inclus dans 12 Systematic reviews Systematic reviews (12 references)

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BACKGROUND: Poor adherence to oral antidiabetics has a negative influence on glycaemic control in type 2 diabetes patients. Real Time Medication Monitoring (RTMM) combines real time monitoring of patients' medication use with SMS reminders sent only if patients forget their medication, aiming to improve adherence. This study aimed to investigate the effect of these SMS reminders on adherence to oral antidiabetics in patients using RTMM and investigate patients' experiences with RTMM. METHODS: Data were collected in a RCT involving 104 type 2 diabetes patients with suboptimal adherence to oral antidiabetics. Fifty-six patients were randomised to receive SMS reminders if they forgot their medication, 48 patients received no reminders. Primary outcome measure was adherence to oral antidiabetics registered with RTMM, measured as: (1) days without dosing; (2) missed doses; (3) doses taken within predefined standardized time windows. Patients' experiences were assessed with written questionnaires. RESULTS: Over the six-month study period, patients receiving SMS reminders took significantly more doses within predefined time windows than patients receiving no reminders: 50% vs. 39% within a 1-h window (p=0.003) up to 81% vs. 70% within a 4-h window (p=0.007). Reminded patients tended to miss doses less frequently than patients not reminded (15% vs. 19%, p=0.065). Days without dosing were not significantly different between the groups. The majority of patients reported positive experiences with RTMM and SMS reminders. CONCLUSION: RTMM with SMS reminders improves adherence of type 2 diabetes patients, especially the precision with which patients follow their prescribed regimen, and is well accepted by patients. TRIAL REGISTRATION: Netherlands Trial Register NTR1882.

Primary study

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A text message programme designed to modify patients' illness and treatment beliefs improves self-reported adherence to asthma preventer medication.

Journal British journal of health psychology
Year 2012
Liens Pubmed DOI

Cet article est inclus dans 9 Systematic reviews Systematic reviews (9 references)

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Objective. While effective preventative medication is readily available for asthma, adherence is a major problem due to patients' beliefs about their illness and medication. We investigated whether a text message programme targeted at changing patients' illness and medication beliefs would improve adherence in young adult asthma patients. Methods. Two hundred and sixteen patients aged between 16 and 45 on asthma preventer medication were recruited from pamphlets dispensed with medication and e-mails sent to members of a targeted marketing website. Participants were randomized to receive individually tailored text messages based on their illness and medication beliefs over 18 weeks or no text messages. Illness and medication beliefs were assessed at baseline and at 18 weeks. Adherence rates were assessed by phone calls to participants at 6, 12, and 18 weeks and at 6 and 9 months. Results. At 18 weeks, the intervention group had increased their perceived necessity of preventer medication, increased their belief in the long-term nature of their asthma, and their perceived control over their asthma relative to control group (all p's &lt; .05). The intervention group also significantly improved adherence over the follow-up period compared to the control group with a relative average increase in adherence over the follow-up period of 10% (p &lt; .001). The percentage taking over 80% of prescribed inhaler doses was 23.9% in the control group compared to 37.7% in the intervention group (p &lt; .05). Conclusion. A targeted text message programme increases adherence to asthma preventer inhaler and may be useful for other illnesses where adherence is a major issue.

Primary study

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A mobile phone short message service improves perceived control of asthma: A randomized controlled trial.

Auteurs Lv Y , Zhao H , Liang Z , Dong H , Liu L , Zhang D , Cai S
Journal Telemedicine journal and e-health : the official journal of the American Telemedicine Association
Year 2012
Liens Pubmed DOI

Cet article est inclus dans 8 Systematic reviews Systematic reviews (8 references)

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OBJECTIVE: Mobile phone short message service (SMS) has been suggested as a potentially powerful tool to improve asthma outcomes, and it can overcome external barriers such as time and distance to participate education programs. We wanted to know whether SMS can help to overcome intrinsic barriers such as perceived control of asthma (PCA). Subjects and METHODS: One hundred fifty outpatients with asthma were randomly assigned to the control, traditional, and SMS groups. Patients in all groups received verbal education based on the Global Initiative for Asthma, and patients in the traditional group received additional individualized asthma action plan for self-management with peak expiratory flow monitoring and recording asthma diary, while patients in the SMS group received additional daily SMS reminders on their mobile phone. The six-item PCA Questionnaire (PCAQ-6), Standard Asthma- Specific Quality of Life [AQLQ(S)], spirometry, blood and induced sputum cell count, follow-up compliance rate, medicine compliance rate, and emergency department (ED) visits data were collected at the initial visit and at 12 weeks. RESULTS: In total, 71 participants completed the trial for analysis. Patients' PCAQ-6 score was significantly increased in the SMS and traditional groups (p &lt; 0.001) after 12 weeks, and the change of patients' PCAQ-6 score in the SMS group was higher than in the traditional group (p = 0.018). Patients in the SMS group had the highest AQLQ(S) score and follow-up rate after 12 weeks. The change in PCAQ-6 score was associated with change in AQLQ(S) score (r = 0.442). Patients in all groups had better forced expiratory volume in 1 s (FEV1%) and fewer ED visits after 12 weeks, but no significant differences were found among the three groups in the changes of FEV1% and blood and induced sputum eosinophil counts and neutrophil counts. CONCLUSIONS: SMS can improve PCA, and it has a greater advantage in improving follow-up rate and asthma-specific quality of life than traditional programs. (PsycInfo Database Record (c) 2022 APA, all rights reserved)

Primary study

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A randomized controlled trial comparing the effects of counseling and alarm device on HAART adherence and virologic outcomes.

Journal PLoS medicine
Year 2011
Liens Pubmed DOI PubMed Central

Cet article est inclus dans 8 Systematic reviews Systematic reviews (8 references)

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<b>BACKGROUND: </b>Behavioral interventions that promote adherence to antiretroviral medications may decrease HIV treatment failure. Antiretroviral treatment programs in sub-Saharan Africa confront increasing financial constraints to provide comprehensive HIV care, which include adherence interventions. This study compared the impact of counseling and use of an alarm device on adherence and biological outcomes in a resource-limited setting.<b>Methods and FINDINGS: </b>A randomized controlled, factorial designed trial was conducted in Nairobi, Kenya. Antiretroviral-naïve individuals initiating free highly active antiretroviral therapy (HAART) in the form of fixed-dose combination pills (d4T, 3TC, and nevirapine) were randomized to one of four arms: counseling (three counseling sessions around HAART initiation), alarm (pocket electronic pill reminder carried for 6 months), counseling plus alarm, and neither counseling nor alarm. Participants were followed for 18 months after HAART initiation. Primary study endpoints included plasma HIV-1 RNA and CD4 count every 6 months, mortality, and adherence measured by monthly pill count. Between May 2006 and September 2008, 400 individuals were enrolled, 362 initiated HAART, and 310 completed follow-up. Participants who received counseling were 29% less likely to have monthly adherence &lt;80% (hazard ratio [HR] = 0.71; 95% confidence interval [CI] 0.49-1.01; p = 0.055) and 59% less likely to experience viral failure (HIV-1 RNA ≥5,000 copies/ml) (HR 0.41; 95% CI 0.21-0.81; p = 0.01) compared to those who received no counseling. There was no significant impact of using an alarm on poor adherence (HR 0.93; 95% CI 0.65-1.32; p = 0.7) or viral failure (HR 0.99; 95% CI 0.53-1.84; p = 1.0) compared to those who did not use an alarm. Neither counseling nor alarm was significantly associated with mortality or rate of immune reconstitution.<b>CONCLUSIONS: </b>Intensive early adherence counseling at HAART initiation resulted in sustained, significant impact on adherence and virologic treatment failure during 18-month follow-up, while use of an alarm device had no effect. As antiretroviral treatment clinics expand to meet an increasing demand for HIV care in sub-Saharan Africa, adherence counseling should be implemented to decrease the development of treatment failure and spread of resistant HIV.

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