Primary studies included in this systematic review

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Primary study

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Long-term nonsurgical control with ulipristal acetate of multiple uterine fibroids, enabling pregnancy.

Giornale American journal of obstetrics and gynecology
Year 2016
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Questo articolo fa parte di 2 Systematic reviews Systematic reviews (2 references)

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Spontaneous Pregnancy Following Ulipristal Acetate Treatment in a Woman with a Symptomatic Uterine Fibroid.

Autori Murad K
Giornale Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC
Year 2016
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Questo articolo fa parte di 2 Systematic reviews Systematic reviews (2 references)

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BACKGROUND: Uterine fibroids (UFs) may impair fertility and promote miscarriage. The optimal treatment for women with UFs who wish to conceive is uncertain. CASE: A 35-year-old woman of African ancestry with a history of recurrent miscarriage (gravida 5, para 0) had a solitary submucosal UF (volume: 102.4 cm(3)) extending into the uterine cavity. Following a three-month course of ulipristal acetate (UPA) 5 mg daily, UF volume decreased to 72.1 cm(3). The patient conceived approximately two months after discontinuing UPA. She had an uncomplicated pregnancy and underwent a planned induction of labour at 38 weeks' gestation. The patient had a normal vaginal delivery of a healthy male infant weighing 3130 g. An ultrasound performed three months post-delivery revealed further reduction in UF volume to 14.5 cm(3). CONCLUSION: This report demonstrates the utility of UPA in the management of women with UFs who desire pregnancy but who opt for non-surgical management.

Primary study

Unclassified

Case report: successful pregnancy after combined preoperative pretreatment with ulipristal acetate and laparoscopic myoma enucleation in deep-seated cervical posterior wall myoma and desire to have children.

Autori Romer T
Giornale J Gynakologische Endokrinologie
Year 2015

Questo articolo fa parte di 2 Systematic reviews Systematic reviews (2 references)

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Primary study

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Successful pregnancy after gigantic uterine fibroids treatment with the help of ulipristal acetate.

Autori Tikhomirov AL
Giornale Problemy Reproduktsii
Year 2015

Questo articolo fa parte di 2 Systematic reviews Systematic reviews (2 references)

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Primary study

Unclassified

Commentary on the article "Pre-treatment with ulipristal acetate before ICSI procedure: a case report" published in Menopause Review 6/2013 (Przegląd Menopauzalny 2013; 6: 496-500).

Autori Wdowiak A
Giornale Przeglad menopauzalny = Menopause review
Year 2014
Links Pubmed DOI PubMed Central

Questo articolo fa parte di 2 Systematic reviews Systematic reviews (2 references)

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Primary study

Unclassified

Successful pregnancy after treatment with ulipristal acetate for uterine fibroids.

Giornale Case reports in obstetrics and gynecology
Year 2014
Links Pubmed DOI PubMed Central

Questo articolo fa parte di 2 Systematic reviews Systematic reviews (2 references)

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This case report presents a clinical pregnancy after ulipristal acetate (UA) to decrease uterine fibroid size. A 37-year-old patient, gravida 1, abortus 1, with uterine fibroids was treated with 5 mg of UA daily for 13 weeks starting eight months after a multiple laparotomic myomectomy. Fibroid shrinkage and restoration of the morphology of endometrial cavity were evaluated in order to allow a subsequent pregnancy. A decrease of the uterine fibroids and a normal morphology of the endometrial cavity were noted by transvaginal ultrasound after treatment. An endometrial biopsy excluded histologic endometrial changes. Three months after the end of UA the patient reported amenorrhea for 5 weeks and a clinical pregnancy was confirmed with transvaginal ultrasound. She underwent a subsequent uneventful pregnancy. Thus, the spontaneous pregnancy after UA to reduce fibroid size may support the potential clinical utility of this selective progesterone receptor modulator in the management of women with pregnancy desire and uterine fibroids after a prior myomectomy. Patients who refuse a new surgical procedure and/or those who are going to undergo assisted reproductive techniques would benefit from UA. It effectively shrinks fibroids, avoids risks of a new surgical procedure, and allows an immediate attempt at conception after the end of treatment.

Primary study

Unclassified

First series of 18 pregnancies after ulipristal acetate treatment for uterine fibroids.

Giornale Fertility and sterility
Year 2014
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Questo articolo fa parte di 3 Systematic reviews Systematic reviews (3 references)

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OBJECTIVE: To study the pregnancy rate after ulipristal acetate (UPA) therapy for fibroids. DESIGN: Retrospective analysis of a series of 52 patients prospectively included in the PGL4001 (ulipristal acetate) Efficacy Assessment in Reduction of Symptoms Due to Uterine Leiomyomata (PEARL) II and III trials. SETTING: Academic hospital. PATIENT(S): Among the 52 patients, 21 wished to conceive upon treatment completion. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Pregnancy rate and live birth rate. RESULT(S): Twenty-one patients attempted to get pregnant, among whom 15 (71%) succeeded, totaling 18 pregnancies. Among these 18 pregnancies, 12 resulted in the birth of 13 healthy babies and 6 ended in early miscarriage. No regrowth of fibroids was observed during pregnancy. CONCLUSION(S): We report the first series of pregnancies achieved after UPA treatment. Our data confirm a sustained long-term effect after UPA therapy.