Hagenbach et al [provisional name] (Delta9-tetrahydrocannabinol for spinal cord injury [provisional name])
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The treatment of spasticity with D9-tetrahydrocannabinol (D9-THC) in patients with spinal cord injury

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Conference IACM 2nd Conference on Cannabinoids in Medicine
Year 2003
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This article is included in 2 Systematic reviews Systematic reviews (2 references)

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Primary study

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The treatment of spasticity with Delta9-tetrahydrocannabinol in persons with spinal cord injury.

Journal Spinal cord
Year 2007
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This article is included in 8 Systematic reviews Systematic reviews (8 references) 1 Broad synthesis Broad syntheses (1 reference)

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Study design:Open label study to determine drug dose for a randomized double-blind placebo-controlled parallel study.OBJECTIVES:To assess the efficacy and side effects of oral Delta(9)-tetrahydrocannabinol (THC) and rectal THC-hemisuccinate (THC-HS) in SCI patients.SETTING:REHAB Basel, Switzerland.METHOD:Twenty-five patients with SCI were included in this three-phase study with individual dose adjustment, each consisting of 6 weeks. Twenty-two participants received oral THC open label starting with a single dose of 10 mg (Phase 1, completed by 15 patients). Eight subjects received rectal THC-HS (Phase 2, completed by seven patients). In Phase 3, six patients were treated with oral THC and seven with placebo. Major outcome parameters were the spasticity sum score (SSS) using the Modified Ashworth Scale (MAS) and self-ratings of spasticity.RESULTS:Mean daily doses were 31 mg with THC and 43 mg with THC-HS. Mean SSS for THC decreased significantly from 16.72 (+/-7.60) at baseline to 8.92 (+/-7.14) on day 43. Similar improvement was seen with THC-HS. We observed a significant improvement of SSS with active drug (P=0.001) in the seven subjects who received oral THC in Phase 1 and placebo in Phase 3. Major reasons for drop out were increase of pain and psychological side effects.CONCLUSION:THC is an effective and safe drug in the treatment of spasticity. At least 15-20 mg per day were needed to achieve a therapeutic effect.Spinal Cord (2007) 45, 551-562; doi:10.1038/sj.sc.3101982; published online 17 October 2006.