Mustian KM
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Tai Chi Chuan, health-related quality of life and self-esteem: a randomized trial with breast cancer survivors.

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Journal Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
Year 2004
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This article is included in 10 Systematic reviews Systematic reviews (10 references)

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GOALS: Health-related quality of life (HRQL) and self-esteem are often diminished among women diagnosed and treated for breast cancer. Tai Chi is a moderate form of exercise that may be an effective therapy for improving HRQL and self-esteem among these women. We sought to compare the efficacy of Tai Chi Chuan (TCC) and psychosocial support (PST) for improving HRQL and self-esteem among breast cancer survivors. PATIENTS AND METHODS: A group of 21 women diagnosed with breast cancer, who had completed treatment within the last 30 months were randomized to receive 12 weeks of TCC or PST. Participants in both groups met three times a week for 60 minutes. HRQL and self-esteem were assessed at baseline, 6 weeks, and 12 weeks. RESULTS: The TCC group demonstrated significant improvements in HRQL, while the PST group reported declines in HRQL, with the differences between the two groups approaching significance at week 12. Additionally, the TCC group exhibited improvements in self-esteem, while the PST group reported declines in self-esteem, with the differences between groups reaching statistical significance at week 12. These findings, coupled with a visual inspection of the raw change scores, support the plausibility of a dose-response relationship concerning Tai Chi. CONCLUSIONS: In this pilot investigation, the TCC group exhibited improvements in HRQL and self-esteem from baseline to 6 and 12 weeks, while the support group exhibited declines. Randomized, controlled clinical trials with larger sample sizes are needed.

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A pilot study to assess the influence of tai chi chuan on functional capacity among breast cancer survivors.

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Authors Mustian KM , Katula JA , Zhao H
Journal The journal of supportive oncology
Year 2006
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This article is included in 9 Systematic reviews Systematic reviews (9 references)

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Treatment of breast cancer can significantly diminish functional capacity in patients months and even years after the completion of treatments. Tai chi chuan (TCC) is a moderate form of exercise that may be an effective therapy for improving functional capacity among breast cancer survivors. We sought to provide pilot data comparing the efficacy of TCC and psychosocial therapy (PST; physical activity control) for improving functional capacity among breast cancer survivors post treatment. Twenty-one women who had completed treatment of breast cancer were randomized to receive TCC or PST 3 times/wk for 12 weeks. Functional capacity was assessed at baseline and at 12 weeks. The TCC group demonstrated significant improvement in functional capacity (specifically aerobic capacity, muscular strength, and flexibility) whereas the PST group showed significant improvement in flexibility only. These data suggest that TCC may be an efficacious intervention for enhancing functional capacity among breast cancer survivors and may support the need for larger randomized, controlled clinical trials to further elucidate these relationships.

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Tai Chi Chuan for breast cancer survivors.

Journal Medicine and sport science
Year 2008
Links Pubmed DOI PubMed Central

This article is included in 8 Systematic reviews Systematic reviews (8 references)

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BACKGROUND/AIMS: Treatment for breast cancer produces side effects that diminish functional capacity and quality of life (QOL) among survivors. Tai Chi Chuan (TCC) is a moderate form of exercise that may improve functional capacity and QOL in these individuals. Women who completed treatment for breast cancer were randomized to receive TCC or psychosocial support therapy for 12 weeks (60 min; three times weekly). RESULTS: The TCC group demonstrated significant improvements in functional capacity, including aerobic capacity, muscular strength, and flexibility, as well as QOL; the psychosocial support therapy group showed significant improvements only in flexibility, with declines in aerobic capacity, muscular strength, and QOL. CONCLUSIONS: The TCC group exhibited significant improvements in functional capacity and QOL. These data suggest that TCC may enhance functional capacity and QOL among breast cancer survivors.

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Health-related quality of life and biomarkers in breast cancer survivors participating in tai chi chuan.

Journal Journal of cancer survivorship : research and practice
Year 2012
Links Pubmed DOI PubMed Central

This article is included in 17 Systematic reviews Systematic reviews (17 references)

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<b>INTRODUCTION: </b>Breast cancer survivors experience diminished health-related quality of life (HRQOL). We report on the influence of tai chi chuan exercise (TCC) on HRQOL and explore associations between changes in HRQOL and biomarkers.<b>METHODS: </b>Breast cancer survivors (N = 21) were randomly assigned to TCC or standard support therapy (SST) for 12 weeks (three times/week; 60 min/session). Interleukin-6, interleukin-8 (IL-8), insulin-like growth factor-1 (IGF-1), insulin-like growth factor-binding protein (IBFBP)-1, IGFBP-3, glucose, insulin, and cortisol were measured pre- and postintervention. Overall HRQOL and subdomains were assessed at preintervention (T1), midintervention (T2) and postintervention (T3) and biomarkers at T1 and T3.<b>RESULTS: </b>The TCC group improved in total HRQOL (T1-T2:CS = 8.54, P = 0.045), physical functioning (T1-T2:CS = 1.89, P = 0.030), physical role limitations (T1-T2 CS = 1.55, P = 0.023), social functioning (T1-T3:CS = 1.50, P = 0.020), and general mental health (T1-T2:CS = 2.67, P = 0.014; T1-T3:CS = 2.44, P = 0.019). The SST improved in social functioning (T1-T2:CS = 0.64, P = 0.043) and vitality (T1-T2:CS = 0.90, P = 0.01). There were relationships between changes in IGF-1 and overall HRQOL (r = -0.56; P &lt; 0.05), physical role limitation (r = -0.68; P &lt; 0.05), and social functioning (r = -0.56; P &lt; 0.05). IGFBP-1 changes were associated with physical role limitations changes (r = 0.60; P &lt; 0.05). IGFBP-3 changes were associated with physical functioning changes (r = 0.46; P ≤ 0.05). Cortisol changes were associated with changes in physical role limitations (r = 0.74; P &lt; 0.05) and health perceptions (r = 0.46; P &lt; 0.05). Glucose changes were associated with emotional role limitation changes (r = -0.70; P &lt; 0.001). IL-8 changes were associated with emotional role limitation changes (r = 0.59; P &lt; 0.05).<b>Discussion/conclusions: </b>TCC may improve HRQOL by regulating inflammatory responses and other biomarkers associated with side effects from cancer and its treatments.<b>Implications For Cancer Survivors: </b>TCC may be an intervention capable of improving HRQOL in breast cancer survivors.