Anticonvulsants to treat post-traumatic stress disorder

Objective: We reviewed the existing literature on the efficacy of anticonvulsants in treating post-traumatic stress disorder. Methods: We performed a literature search using PubMed, EMBASE and the Cochrane database on 30 September 2013. Randomized, controlled studies that investigated the ef ficacy of anticonvulsants for post-traumatic stress disorder were included in this review. Studies with retrospective designs, case reports and case series were excluded. Results: A total of seven studies met the inclusion criteria for this review. Three studies used topiramate with negative findings regarding its efficacy. Two studies used divalproex, both of which failed to show superiority over placebo. One study used lamotrigine, with favourable results, and one study used tiagabine, with negative results. Conclusions: Future long-term studies with larger sample sizes are needed to investigate the clinical utility of anticonvulsants for post-traumatic stress disorder treatment.