Antidepressant analgesia in rheumatoid arthritis.

Categoría Estudio primario
RevistaThe Journal of rheumatology
Año 1989
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Forty-seven patients with definite rheumatoid arthritis (RA) were treated in a 32 week, double blind, crossover trial of amitriptyline, desipramine, trazodone, and placebo. All drug regimens produced significant changes on pain measures relative to baseline, but only amitriptyline exceeded placebo. Amitriptyline was associated with a significant reduction in the number of painful/tender joints. Our study supports the efficacy of a moderate dose of amitriptyline as an adjunct drug for the treatment of pain in both depressed and nondepressed patients with RA.
Epistemonikos ID: 26b49b1ef9eff01176025b43da75291ba3dc6e57
First added on: Nov 19, 2011