Ulceración superior gastroduodenal en pacientes con artritis tratados con celecoxib

CRD COMMENTARY:

The review addressed a clearly defined question with clear criteria for selecting the trials. A wide-ranging search strategy enabled it to include unpublished trials. Double-blind, randomised controlled trials analysed on an intention-to-treat basis provide a good evidence base, provided that the trials are well-conducted, which we were not able to determine. There was no report of any further validity assessment beyond the stated study design. The methods used to determine the eligibility of the studies and to extract the data were not described. The individual studies included in the review were well described.
Tests for heterogeneity were carried out; since no significant heterogeneity was found, the statistical method used to pool the results was appropriate.
The authors' conclusions appear justified, although it should be noted that many of the results are based on only one or two trials.