Efectividad de Povidona Yodada y Peróxido de Hidrógeno en Coronavirus: una Revisión de la Literatura

Objective: To evaluate the effectiveness of PVP-I and HP as an antiseptic in reducing the viral load of Coronavirus, in addition to determining its effective concentration and application methods to be incorporated in Biosafety protocols. . Materials and Method: A research was conducted using PubMed, Embase, and Web of Science databases, applying the search algorithm: “(coronavirus AND (povidone-iodine OR hydrogen peroxide))” and a publication filter of the last five years. Inclusion criteria: articles published between 2015-2020; in vivo and in-vitro articles; no language restriction. Exclusion criteria: reviews; not relevant; duplicity. Results: The search generated 34 results where 17 were duplicates, which meant that 17 articles met the selection criteria. Ten articles evaluated "Oral and nasopharyngeal rinses" (ONR) and, seven assessed "Extraoral surfaces" (ES). For ONR, it was established a viricidal effect of PVP-I from concentrations of 0.23%, and for HP, it was verified an effect from 3%, both were evaluated after 15 seconds of application, with different results. In ES, the use of PH steam (HPV) stands out, demonstrating effectiveness, and the use of PVP-I from 7.5%. Conclusion: Due to the similarity of receptors and molecular structure of the different Coronaviruses, the use of viricidal agents could be common and effective. The use of 0.23% PVP-I mouthwash for 15 seconds is recommended. In extraoral disinfectants, HPV is used to reduce the viral load of SARS-CoV-2 as a complement to biosafety barriers, minimizing the risks of the spread of COVID-19.