El metanálisis de los inhibidores de la bomba de protones en el tratamiento de úlceras pépticas sangrantes

CRD COMMENTARY:

This was a reasonably well-conducted and reported review. The inclusion criteria were appropriate to the review question, specifying relevant aspects such as the participants, interventions, study design and outcomes. The search for evidence covered three databases and the reference lists of retrieved articles. Data from the included trials were presented in adequate detail and the trials were summarised appropriately. However, the search was limited to the English language literature, which may have led to relevant studies being missed. It was also unclear how many of the reviewers were involved in the selection and data extraction of the studies. The authors indicated that their inclusion and exclusion criteria obviated the need for any formal assessment of methodological quality. However, it would have been useful to have examined the results of the included trials in the context of their individual attributes (e.g. blinding) and overall methodological quality.