Parenteral immunonutrition in patients with acute pancreatitis: A meta-analysis of randomized controlled trials

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Categoría Revisión sistemática
RevistaWorld Chinese Journal of Digestology
Año 2014
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Aim: To evaluate the effects of parenteral immunonutrition on clinical outcomes [infectious complications, length of hospital stay (LOS) and mortality] in patients with acute pancreatitis.
Methods: Pubmed, Medline, Embase, Science Direct, CBM, Springer link, VIP and CNKI were electronically searched before 31st May 2014 to collect the articles on parenteral immunonutrition in acute pancreatitis. The quality of the included trials was assessed according to the inclusive and exclusive criteria, and the data were extracted and analyzed using RevMan 5.2.7 software.
Results: A total of seven randomized controlled trials studies with 264 pancreatitis patients were included. The number of patients receiving parenteral immunonutrition was 130 and the number of patient receiving standard parenteral nutrition was 134. Meta-analysis showed that parenteral immunonutrition significantly reduced the risk of infectious complications (RR = 0.56, 95%CI: 0.39-0.82, P = 0.002) and mortality (RR = 0.23, 95%CI: 0.10-0.52, P < 0.001). LOS was also shorter in patients who received immunonutrition (RR = -5.63, 95%CI: -9.69--1.57, P = 0.007).
Conclusion: Immunonutrients like glutamine and omega-3 fatty acids added to parenteral formulas can improve prognoses in patients with acute pancreatitis. Our findings still need to be verified by large, multicenter prospective randomized controlled trials.
Epistemonikos ID: 6b7162b28a9188ffa0c0d5b4d0253407e49fb674
First added on: Nov 22, 2016