Effect of clomethiazole on nocturnal sleep pattern in cerebral arteriosclerosis

In 32 older patients treated as outpatients for arteriosclerotic blood flow disturbances in the Ansbach district hospital over a period of 28 days a systematic watch was kept on the depth of night sleep from 10 p.m. five times with a two hour interval during placebo or chlomethiazole treatment. The patients received four capsules of 500 mg active substance or placebo. The optimal long term action of the clomethiazole therapy appeared only after 10 days on a uniform dose. The act of falling asleep and sleeping sufficiently were favorably influenced. There were no hangover symptoms. By and large normalization of the sleep-waking rhythm could be observed.