Sulpirida aumento en las personas con esquizofrenia responden parcialmente a la clozapina. Un estudio doble ciego, controlado con placebo.

Hypothesized that a combined regimen of clozapine, a relatively weak D₂-dopaminergic antagonist, and sulpiride, a selective D₂ blocker, would demonstrate a greater antipsychotic efficacy by enhancing the D₂ blockade of clozapine. 28 adults with schizophrenia, previously unresponsive to atypical antipsychotics and only partially responsive to current treatment with clozapine, received, double-blind, 600 mg/day sulpiride or placebo, in addition to an ongoing clozapine treatment. The clinical status was evaluated before, during, and at the end of 10 wks of sulpiride addition using the Brief Psychiatric Rating Scale (BPRS), Scale for the Assessment of Positive Symptoms (SAPS), Scale for the Assessment of Negative Symptoms, and Hamilton Rating Scale for Depression. The clozapine-sulpiride group exhibited substantially greater and significant improvements in positive and negative psychotic symptoms. About half of them, characterized by a younger age and lower baseline SAPS scores, had a mean reduction of 42.4% and 50.4% in their BPRS and SAPS scores, respectively. (PsycInfo Database Record (c) 2021 APA, all rights reserved)