Chemotherapy-related amenorrhea in premenopausal women with breast cancer.

Autores Lee S, Kil WJ, Chun M, Jung YS, Kang SY, Kang SH -Más
Categoría Estudio primario
RevistaMenopause (New York, N.Y.)
Año 2009
Enlaces Pubmed, DOI
OBJECTIVE: To report the incidence of chemotherapy-related amenorrhea (CRA) from chemotherapy with/without adjuvant endocrine therapy in premenopausal women with breast cancer and to analyze the related factors. DESIGN: From January 2000 to August 2006, 326 premenopausal women (or=40 y). CRA occurred in a total of 223 (68%) women: 43% in group 1 and 85% in group 2 (P < 0.001). Despite CRA, 14% resumed menstruation: 24% in group 1 and 11% in group 2. Another 40 (12%) women had less than 6 months of menstruation interruption. Permanent CRA was related with age at diagnosis and use of adjuvant endocrine therapy (P < 0.05). In this study, there were four pregnancies, two of which resulted in therapeutic abortion due to ongoing chemotherapy. CONCLUSIONS: This study confirmed that the rate of CRA depends on age at diagnosis and the use of adjuvant endocrine therapy. It is essential to inform young women of reproductive age of the possibility of amenorrhea or resumption of menstruation and contraceptive options.
Epistemonikos ID: ccb70eb2c2c854b6d2f021d4a68eac8c1a86c261
First added on: May 30, 2014