Effectiveness and Safety of Tofacitinib for Ulcerative Colitis: Systematic Review and Meta-analysis.

BACKGROUND:

The objective of our systematic review and meta-analysis was to evaluate the effectiveness and safety of tofacitinib in the treatment of moderate-severe ulcerative colitis (UC).

METHODS:

We searched Medline, Embase, Web of Science, and Cochrane Central to identify articles and abstracts reporting efficacy or safety data on tofacitinib use in UC. Primary outcome assessed was remission. Secondary outcomes included clinical response, steroid free remission, and adverse events (AEs).

RESULTS:

A total of 26 studies were included. The rates of remission were 29.81% [95% confidence interval (CI): 22.37%-37.25%, I2: 90%] at week 8, 32.27% (95% CI.: 27.67%-36.88%, I2: 42%) at 6 months and 38.03% (95% CI.: 33.59%-42.48%, I2: 0%) at 1-year. Clinical response rates were 59.41% (95% CI.: 55.03%-63.94%, I2: 61%) at week 8, 48.99% (95% CI.: 36.92%-61.06%, I2: 91%) at 6 months and 50.87% (95% CI.: 42.16%-59.58%, I2: 67%) at 1-year. Odds ratio of clinical response at week 8 in biologic naive versus biologic experienced patients was 1.59 (95% CI.: 0.54-4.63). Pooled incidence rate for serious infections, major adverse cardiovascular events, and nonmelanotic squamous cell malignancies across all doses was 4.41 per 100-patient years (PYs) (95% CI.: 2.32-8.38 per 100-PY, I2: 78%), 0.91 per 100-PY (95% CI.: 0.43-1.93 per 100-PY, I2: 37%) and 0.91 per 100-PY (95% CI.: 0.61-1.34 per 100-PY, I2: 0%), respectively. Higher dose was associated with an increased frequency of AEs.

CONCLUSIONS:

While the overall efficacy and safety of tofacitinib in moderate-severe UC is consistent with clinical trial data, the dose dependent increase in AEs highlights the significance of early dose de-escalation. Rate of clinical response after tofacitinb induction was similar in biologic naive and biologic experienced patients.