Efecto de la alta dosis Fluimucil en la función pulmonar de pacientes con fibrosis pulmonar idiopática

OBJECTIVE: To explore the effective methods to improve the pulmonary function and life quality of patients with idiopathic pulmonary fibrosis (IPF)．METHODS: 48 IPF patients were randomly divided into two groups，each group includes 24 cases．Group A was treated with prednisone 05mg/kg per day orally, reduce half of the dosage 4 weeks later and Fluimucil 600 mg three times per day orally, while group B with prednisone 0.5 mg/kg per day orally, reduce half of the dosage 4 weeks later．The clinical manifestation, pulmonary function testing, high-resolution CT of the chest, arterial blood gas analysis were observed before and 3 months after treatment．RESULTS: There was significant difference in Group A (P< O.05) but no significant difference in Group B (P> 0.05) before and after treatment in the pulmonary function testing and arterial blood gas analysis．There was significant difference after treatment in the pulmonary function testing and arterial blood gas analysis between Group A and Group B (P< 0.05)．There was significant difference after treatment in the clinical manifestation, high-resolution CT of the chest and between Group A and GroupB (P< O.05)．CONCLUSION: High dose Fluimucil can ameliorate the pulmonary function, relieve the symptom of short breath of patients with idiopathic pulmonary fibrosis．