Hepatotoxicidad por fármacos antituberculosos en Pediatría

The clinical profile of hepatotoxicity induced by tuberculosis drugs varies and the re-introduction of therapy for patients who developed this condition is controversial. 5 pediatric cases treated throughout a period of 10 years in the Pediatric Department of Hipolito Unanue National Hospital are presented. 2 individuals showed an asymptomatic increase of transaminases, 2 individualshad hepatitis, and 1 individual had acute liver failure. Most patients were female school students. Malnutrition and therapy continuation once the hepatic damage was started were found to be the risk factors. A staged reintroduction scheme for these agents after recovery from hepatitis is proposed.