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In a randomized, double-blind, controlled study, 153 patients with claudication were each given either 20 infusions of Na2EDTA or 20 infusions of saline. Walking distances and ankle/brachial indices were measured before, during, and after treatment. In 30 patients, angiograms and transcutaneous oxygen tensions were obtained before, during, and after treatment. The patients' subjective evaluations of the effect of treatment were also recorded. It is concluded that EDTA chelation therapy has no effect in patients with intermittent claudication in the legs caused by arteriosclerosis.
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We document racial trends in chronic conditions among older men between 1910 and 2004. The 1910 black arteriosclerosis rate was six times higher than the white 2004 rate and more than two times higher than the 2004 black rate. We argue that blacks' greater lifelong burden of infection led to high arteriosclerosis rates in 1910. Infectious disease, especially respiratory infections at older ages and rheumatic fever and syphilis at younger ages, predicted arteriosclerosis in 1910, suggesting that arteriosclerosis has an infectious cause. Additional risk factors for arteriosclerosis were being born in the second relative to the fourth quarter, consistent with studies implying that atherogenesis begins in utero, and a low body mass index, consistent with an infectious disease origin of arteriosclerosis.
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Forty-two married couples (30–69 years of age) were followed for 4 years with yearly measurements of risk factors for arteriosclerosis. Advice was given concerning relaxed, enjoyable exercise (mainly running at 10–13 km hr−1). Each person served as his own control by comparison of the first and the last yearly status.Both the group of women and the group of men significantly improved (two sided p š 0.005) their maximum oxygen uptake, and reduced their blood glucose concentration (two-sided p < 0.01). S-cholesterol (for the group of men) was reduced statistically significantly (two-sided p < 0.01). At the first examination the groups of women and men with the lowest maximum oxygen uptake (group I) had higher average values for risk factors than the more active groups (group II). At the final examination almost all persons had improved their maximum oxygen uptake, so none of the other risk factor differences between groups I and II were statistically significant.Both the women and the men improved their well being and their health profile as evaluated in terms of risk factors for arteriosclerosis. Exhaustive exercise was not necessary for beneficial effects.