Addition of teicoplanin or vancomycin for the treatment of documented bacteremia due to gram-positive cocci in neutropenic patients with hematological malignancies: microbiological, clinical and economic evaluation.

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类别 Primary study
期刊Chemotherapy
Year 2004
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对发热病人124例恶性血液病进行一个前瞻性,随机,双盲试验,比较与万古霉素,替考除了最初的经验性丁胺卡那霉素,头孢他啶后,记录菌血症由于革兰氏阳性球菌的方案。在入学,两组患者年龄,性别方面的可比性,相关血液疾病和中性粒细胞减少的持续时间。治疗成功率分别为55/63(87.3%),替考拉宁组和万古霉素组(P = 0.560),56/61(91.8%)。平均治疗时间相似,分别为12.2和11.4天(P = 0.216)。与替考拉宁治疗的患者仍略高于万古霉素(4.9 - 4.0天)(P = 0.013),治疗这些发热。13例患者经历了药品不良反应,但没有任何两手臂显着差异。隔离葡萄球菌表现出易感性的进步和显着的下降,在多年研究的两种糖肽。进行的经济分析表明,除万古霉素是节约成本。
Epistemonikos ID: 3c25f86e5b208d0cc35ae1424f0d04fcb7da4d8a
First added on: Jun 08, 2011
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