Cerebrospinal fluid analysis in the workup of GLUT1 deficiency syndrome: a systematic review.

Machine translation Machine translation
类别 Systematic review
期刊JAMA neurology
Year 2013
血色素沉着症(HFE)基因的变化是否会增加阿尔茨海默病(AD)风险仍未确定。我们进行了荟萃分析,以便系统地总结可能的关联。通过搜索PUBMED,Web of Science和EMBASE数据库进行研究,并对检索的研究结果进行筛选。根据研究的异质性,使用随机效应或固定效应比值比(OR)和95%置信区间(CI)联合测量。对于C282Y多态性,我们没有使用来自22项研究的数据找到任何关联,包括4,365例和8,652例对照。对于H63D多态性,根据17项研究中的2,795例和7,424例对照,我们观察到显着的关联(等位基因对比:OR = 0.902,95%CI = 0.819-0.994,P = 0.037;次等位基因型:OR = 0.887,95%CI = 0.790-0.996,P = 0.043)。在此荟萃分析中没有发现出版偏倚。现有证据的合成支持HFE H63D多态性突变体对AD风险起着保护作用。
Epistemonikos ID: 3fbefefa4e4bd9a4c3159ffe6fa2a03d2f1f01ce
First added on: Feb 03, 2014
Warning
This is a machine translation from an article in Epistemonikos.

Machine translations cannot be considered reliable in order to make health decisions.

See an official translation in the following languages: English

If you prefer to see the machine translation we assume you accept our terms of use