Treatment of Salmonella gastroenteritis with ampicillin, amoxicillin, or placebo.

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类别 Primary study
期刊Pediatrics
Year 1980
連結 Pubmed, DOI
在一项随机，前瞻性，双盲研究中，婴儿和儿童用简单的沙门氏菌肠胃炎的治疗（15例）与氨苄青霉素，阿莫西林（15例）或安慰剂组（14例）。抗生素的剂量为100 mg / kg /天，四个等分的剂量给予五天。有没有显着受益于抗生素治疗腹泻的持续时间（8.8，7.3，和7.2天，分别手段）或沙门氏菌从粪便培养（的手段率为41.3％，37.0％，和20.9天，分别）恢复的时间。细菌学复发安慰剂治疗的患者中没有观察到，但氨苄青霉素（53％）和8名患者给予阿莫西林（53％），复发率（P = 0.003）。复发中分离出的沙门氏菌仍然容易在体外的抗生素。细菌学复发的16例患者中6例（38％）伴有复发性腹泻。它的结论是氨苄青霉素或阿莫西林治疗提供了简单的沙门氏菌肠胃炎患者没有任何好处，细菌学和症状复发的风险大大增加。
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Epistemonikos ID: 4a1464e36f8cc77415e4c697572a1c01c1302afd
First added on: Nov 17, 2012
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