Comparison of efficacy and safety of teicoplanin and vancomycin in children with antineoplastic therapy-associated febrile neutropenia and gram-positive bacteremia.

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类别 Primary study
期刊Journal of chemotherapy (Florence, Italy)
Year 2000
連結 Pubmed, DOI
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比较其疗效和安全性，替考拉宁和万古霉素随机管理的32个儿童在肿瘤相关中性粒细胞减少（<1000/microl）52革兰氏阳性菌血症。患者主要是患有血液系统恶性肿瘤。 25五集分别用替考拉宁（10毫克x公斤（-1）微型（-1））和21万古霉素（40毫克x公斤（-1）微型（-1））加头孢他啶，奈替米星。六集是因为以前有“红色人替考拉宁治疗”的反应，万古霉素。葡萄球菌（金黄色葡萄球菌12％）来自50个事件和草绿色链球菌分离2。在3〜4天的解热作用发生在31分之29（93.5％）替考拉宁治疗和18/21（85.7％）万古霉素治疗的事件。全部12替考拉宁，万古霉素治疗和13/13处理与3〜4天的重复事件表明血液培养微生物的反应。两个替考拉宁，万古霉素治疗，3治疗的患者需要抗真菌剂。轻度肾功能不全出现在5万古霉素治疗的那是没有纠正患者停药。虽然这两种糖肽展览平等临床疗效和微生物，替考拉宁是不太可能诱发过敏反应或在儿童肾毒性。
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Epistemonikos ID: 5a65dac32114e76fe4a8f840d718c7be39cd7e4d
First added on: Jun 08, 2011
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