Measles incidence, case fatality, and delayed mortality in children with or without vitamin A supplementation in rural Ghana.

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类别 Primary study
期刊American journal of epidemiology
Year 1997
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:数据对麻疹发病率,急性病死率,死亡率,收集和延迟期间,以社区为基础,双盲,安慰剂对照,随机维生素A补充剂的审判过程中对儿童年龄0-95个月的25443农村,北部加纳1989年至1991年。这些儿童麻疹疫苗的覆盖率为48%。总的估计麻疹发病率是每1000儿童为24.3岁,急性病死率为15.7%。没有显着增加的幸存者麻疹急性期死亡率与对照组相比(率比= 1.22,95%可信区间(CI)0.65-2.30)。报告发病率和病死率均较高,在家庭中父亲的教育程度低,在干燥的季节,在未接种疫苗的儿童,病死率在营养不良的儿童高。发病率并没有性别差异,但急性病例病死率在女生比男生略高(胜算比= 1.3,95%CI为0.9-2.1)。麻疹发病率低于A,维生素,补充组(23.6每千人儿童年)高于安慰剂组(28.9每千名儿童年),但差异无统计学意义(P = 0.33)。其中946麻疹集群随机接受维生素A或安慰剂的情况下,没有急性麻疹病例死亡率显着差异的维生素之间,补充和安慰剂组(15.4对比14.5%,分别%)。维生素的生物学A对后续临床表现和严重程度麻疹补充需要进一步澄清。
Epistemonikos ID: 5cbf0d02356ac753125e5ef6eabbd6da0e10287d
First added on: Jun 08, 2011
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