Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial.

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类别 Primary study
期刊Gastroenterology
Year 2003
連結 Pubmed, DOI
背景与目的：我们最近记录了一个高度集中的益生菌制剂在预防（的VSL＃3）疗效爆发与慢性憩室炎患者。这项研究的目的是要比较的VSL＃3的能力相比，防止在第一年后回肠袋肛管吻合术治疗急性憩室炎的发病安慰剂益生菌治疗。方法：40谁行回肠袋肛管吻合术治疗溃疡性结肠炎的病人被随机连续后立即收到回肠造口术或VSL的＃3（1包含9000亿细菌/天）（20例）或相同的安慰剂（n = 20）关闭1年。病人被评定临床，内镜，病理和后1，3，6，9，12个月。健康相关生活质量进行评估使用炎症性肠病问卷。结果：20例患者（10％）治疗的VSL＃3的急性憩室炎发作的比对20例（40％）与安慰剂（log - rank检验治疗和Z = 2.273 8两个; P <0.05） 。与确定的VSL＃3，在治疗炎症性肠病问卷评分显着改善，而这不是用安慰剂的情况。结论：与治疗的VSL＃3是在预防急性憩室炎发作有效，提高了与回肠袋肛管吻合术患者的生活质量。
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Epistemonikos ID: 5dbec2b1d1326a02ec85f0b2b7b5f4676e7fcd1b
First added on: Jun 08, 2011
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