A comparison of masking effects of haloperidol versus molindone in tardive dyskinesia.

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作者
类别 Primary study
期刊Schizophrenia research
Year 1991
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实验方法用于比较两个精神病药物的掩蔽效应 - 吗茚酮和氟哌啶醇 - 18抗精神病药物治疗的精神分裂症患者表现出操作上定义的戒断迟发性运动障碍加剧。一个星期后,这两种药物在预先确定的前期研究精神病的剂量相当于一个,molindone屏蔽的总的目标分数显著较少(12%)比氟哌啶醇(27%)。同样地,在第二周时,这些抗精神病药的剂量相当于200%的预研究剂量,吗茚酮掩蔽总AIMS得分显着较少(23%)相比,氟哌啶醇(53%)。这一发现被认为有几种解释。这项研究表明,可行性的一种方法,可以提供一个模型,了解精神病药物的药理差异。
Epistemonikos ID: 7084786d1ba7af2a23b0cb90d8ea335a27e7c2ae
First added on: Nov 06, 2012
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