Dual-centre, double-blind, randomised trial of lymphoblastoid interferon alpha with or without steroid pretreatment in children with chronic hepatitis B.

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类别 Primary study
期刊Liver
Year 1995
連結 Pubmed, DOI

此文章收錄於 1 Systematic review Systematic reviews (1 reference)

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三十五岁以下儿童慢性HBV感染，HBV-DNA和东亚运动会的血清阳性和HBcAg在肝组织进行治疗淋巴母细胞的人α-干扰素（16例）或无（19例），强的松龙预处理。患者的双盲，随机，接受类固醇或安慰剂4周，2周后，5年或10 MU/m2干扰素12周。电子抗-E血清学转换率达到48％，远远高于自发转阴率。“泼尼松龙吸”的影响无统计学意义。在这两个群体（44％泼尼松龙/干扰素和干扰素单独的后53％），HBeAg清除。无论是治疗的反应并没有相关的治疗前血清转氨酶。HBV-DNA或组织活动的程度。干扰素的耐受性良好，副作用少比成人严重，并不会导致暂停的治疗。
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Epistemonikos ID: 72eff5385dd18ff9d3d05234dc26b0566047ee76
First added on: Nov 26, 2012
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