Calcitonin therapy in central giant cell granuloma of the jaw: a randomized double-blind placebo-controlled study.

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类别 Primary study
期刊International journal of oral and maxillofacial surgery
Year 2006
連結 Pubmed, DOI
与中央的巨细胞肉芽肿患者降钙素治疗的成功使用已被证明在数个病例报道。在一项前瞻性，随机，双盲，安慰剂对照的临床试验中，14例1病理证实的中央巨细胞肉芽肿和正常的钙和甲状旁腺激素血清进行了研究，2年以​​上。患者采用鼻内鲑鱼降钙素（200 IU /天）或安慰剂，每天一次。安慰剂对照期为3个月，1年后所有患者降钙素治疗。在安慰剂对照研究阶段（3个月）结束时，在治疗结束（15个月的时间点为12或15个月降钙素治疗的患者），并在6个月的后续治疗的反应进行了评估。志（2）测试是用来比较减少肿瘤的患者比例> / = 10％在3个时间点的人口之间的预处理测量：观察安慰剂组和降钙素组之间无显着差异。在6个月的随访了时间点，下降了37.9％（95％CI 31.3-44.5％）的7例总的肿瘤体积平均减少量在这个分组> / = 10％。没有观察到完全缓解。
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Epistemonikos ID: 74020c0aee93261e011076713d4753a3033f9bd0
First added on: Apr 30, 2012
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