Pantoprazole is superior to ranitidine in the treatment of acute gastric ulcer.

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类别 Primary study
期刊Scandinavian journal of gastroenterology
Year 1995
連結 Pubmed, DOI

此文章收錄於 1 Systematic review Systematic reviews (1 reference)

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背景：泮托拉唑是一种新开发的胃H + / K + - 腺苷三磷酸酶抑制剂，对胃酸分泌一种强效和长效抑制作用。
方法：在一项双盲多中心临床研究，在德国28个中心，泮托拉唑（40毫克早餐前）进行了比较与雷尼替丁（300毫克睡前）就愈合率，时间，直到愈合，症状缓解，和耐受性。总共有248例门诊良性​​胃溃疡患者。
结果：愈合速度2，4和8周后为37％，87％和97％，分别在雷尼替丁组中的泮托拉唑和19％，58％和80％。两组之间的差异有显著2周（P <0.01），4周（P <0.001），8周（P <0.001;科克伦/曼特尔 - Haenszel法）。溃疡愈合与泮托拉唑（; Uleman的U检验，P <0.001），显著加快进行。两种治疗的耐受性良好。
结论：泮托拉唑似乎优于雷尼替丁在胃溃疡愈合。
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Epistemonikos ID: ac09a8cf8f80f5d702dfeecc18cbe9fb193aece0
First added on: Oct 07, 2013
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