Efficacy of BIO K+ CL1285 in the reduction of antibiotic-associated diarrhea - a placebo controlled double-blind randomized, multi-center study.

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类别 Primary study
期刊Archives of medical science : AMS
Year 2010
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简介:抗生素相关性腹泻(AAD)是一个经常遇到的不良事件抗生素。证据表明益生菌可能是有益的,在预防和减少的严重性AAD。
材料与方法:成人患者的抗生素3-14天,参加由加拿大8个中心。研究治疗随机以1:1的比例BIO-K + CL1285(或安慰剂(®))开始的24小时内服用5天之后终止antibiotherapy。患者随访研究治疗后21天最后一次给药。主要成果是,AAD的严重程度和发病率。严重性测定的总天数,腹泻的患者人数和发病率被定义为至少有一天腹泻超过总数的患者参加了这项研究。
结果:216例患者被随机分配到BIO-K +和221安慰剂。平均(SD)与腹泻的天数为1.19。(3.20)天,安慰剂组和0.67(2.05)天BIO-K + CL1285((®))(P = 0.040)。调整后的多元线性回归结果表明,腹泻持续时间为BIO-K + CL1285()和安慰剂组减少了51.5%,(B [SE] = 0.515 [0.256],P = 0.045)。腹泻的发生率分别为21.8%BIO-K +和29.4%,安慰剂组(OR = 0.667,P = 0.067)。多因素Logistic回归分析,结果表明,在BIO-K +与服用安慰剂的患者AAD调整后的比值比为0.627(P = 0.037)。研究治疗的耐受性良好。
结论:BIO-K +是有效预防和减少AAD的严重性,在接受抗生素治疗的患者在医院的环境。
Epistemonikos ID: ad7a69df53513211bf7ea2c62eaf2feabdf9dfda
First added on: Feb 01, 2013
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