[Prevention of post-operative nausea and vomiting. Randomised comparison of dolasetron versus dolasetron plus dexamethasone].

Machine translation Machine translation
类别 Primary study
期刊Der Anaesthesist
Year 2003
連結 Pubmed, DOI
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背景：术后恶心和呕吐（PONV）是手术后常见的并发症。本研究的目的是，以评估疗效联合多拉司琼联合地塞米松与多拉司琼单独就呕吐症状的发生率和严重程度和患者的满意度。
方法：在一项前瞻性，随机，双盲研究中，150例患者，子宫切除术或乳房手术被分配到以下两组：A组多拉司琼口服50毫克和50毫克，B组多拉司琼口服加静脉注射8 mg地塞米松。后续手术后24小时。
结果：A组PONV明显更频繁（28％）相比，B组（12.0％）。多拉司琼（8.0％）的患者相比，接受多拉司琼联合地塞米松（0％）患者呕吐的发生率显着降低。此外，病人满意度显着高于B组相比，A组大约6或7需要额外的地塞米松治疗的患者，而不是一个病人的安慰剂干预（即从PONV免费），否则谁也受益于遭受PONV。
结论：静脉注射地塞米松口服多拉司琼结合，进一步提高多拉司琼的止吐效果。有了一个数量需要治疗的约6个额外的好处可能被视为临床相关。
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Epistemonikos ID: b27f68654a8e0009fb5beec4062381c74b53a490
First added on: Nov 19, 2012
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