Effects of nilvadipine on the cardiovascular responses to tracheal intubation.

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类别 Primary study
期刊Journal of clinical anesthesia
Year 1992
連結 Pubmed, DOI
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研究目的：尼伐地平口服衰减高血压反应喉镜和气管插管的临床疗效。
设计：对照，随机，双盲研究。
地点：在一所大学医院的择期手术麻醉诱导。
患者：30名血压正常的患者（ASA I级），择期手术的患者分为三组，每组10例。
干预：要么2毫克尼伐地平，尼伐地平，4毫克或安慰剂（对照组），口服麻醉诱导前90分钟。麻醉诱导静脉注射硫喷妥钠5毫克/公斤，促进气管插管维库溴铵0.2毫克/千克。在麻醉过程中，通风协助或1％安氟醚和50％的一氧化二氮（N2O）氧控制。尝试喉镜持续30秒2分钟后给药硫喷妥钠和维库溴铵。
测量及主要结果：接受安慰剂的患者表现出显着增加，平均动脉压（MAP）与气管插管和心脏速率。地图增加气管插管后，尼伐地平治疗的患者比对照组（p小于0.05）显​​着较低。然而，无论是尼伐地平剂量的减毒心动过速响应插管。
结论：在麻醉诱导前口服尼伐地平是一种简单实用的方法，用于衰减标准选修额外1％安氟醚N2O麻醉诱导下喉镜和气管插管后的升压反应。
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Epistemonikos ID: b332d6f8bac870fe7e2b62f1b286ff2f4fc1d77f
First added on: Jul 22, 2013
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