Beneficial effect of prednisolone withdrawal followed by human lymphoblastoid interferon on the treatment of chronic type B hepatitis in Asians: a randomized controlled trial.

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类别 Primary study
期刊Journal of hepatology
Year 1994
連結 Pubmed, DOI

此文章收錄於 2 Systematic reviews Systematic reviews (2 references)

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评估干扰素的效果和效益泼尼松龙在东方慢性活动性乙型肝炎患者的预处理，120中国男患者被随机分配接受：1）A组：泼尼松龙为期4周的课程没有治疗2周然后是12周的课程的人淋巴母细胞干扰素，4至6 MU/m2肌注2）B组：A组，但与安慰剂组给予泼尼松龙3）C组：安慰剂18周的课程。在治疗结束时（A对B：P = 0.054，A组与C，清除血清乙肝病毒DNA和e抗原（完全缓解）取得了21％的A组，B组和C组5％ ：对<0.01）。当评估结束后12个月的治疗，完全缓解率为46％，在A组，B组的24％和25％，C组（P <0.05）。与基线丙氨酸转氨酶<或= 200 U / L，表现出更好的响应干扰素泼尼松龙撤出后（48％）比用干扰素治疗组（20％，P = 0.056）和未治疗者（11％，P <0.01）。与基线血清乙肝病毒DNA <或= 1000皮克/毫升时，也表现出了较高的完全缓解率与强的松龙（59％）预处理后单独使用干扰素（29％，P = 0.084）或未经处理的（22 ％，P <0.03）。一个对治疗的反应是最强的独立预测泼尼松龙撤回（P <0.05）。没有应答失去了B型肝炎表面抗原（摘要截断250字）
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Epistemonikos ID: c7cf300508e825fb551081eee3932008033c293f
First added on: Nov 26, 2012
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