Therapeutic Hypothermia and the Risk of Hemorrhage: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

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类别 Systematic review
期刊Medicine
Year 2015
連結 Pubmed, DOI, PubMed Central

此文書包括 22 Primary studies 22 Primary studies (22 references)

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目的：本研究的目的是确定开放性骨折固定术后感染发展的危险因素。方法：对30多年来所有科学文献进行全面检索，以确定患者，创伤，诊断和治疗相关的危险因素。根据一种或多种危险因素评估感染性并发症时的研究。进行了荟萃分析。计算了具有95％置信区间的风险比（RR）或风险差异（RD）。结果：共纳入手稿116份。男性性别（RR 1.42），糖尿病（DM）（RR 1.72），吸烟（RR1.29），下肢骨折（RR 1.94），Gustilo-AndersonⅢ级开放性骨折（RR 3.01），污染骨折（RR 7.85 ）和多发性硬化患者（RR 1.49）被认为是传染性并发​​症发展的统计学显着的危险因素。在治疗相关危险因素中，只有脉冲灌洗与较高的感染并发症发生率相关（RR 2.70）。结论：在现有文献中已经确定了许多开放性骨折后感染发展的危险因素。这些因素仍应在多变量模型中进行独立性测试。需要进行前瞻性观察性研究，以确定和定量开放性骨折固定后感染的个别危险因素。
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Epistemonikos ID: d34d6eec0a37ab729a56207f863d86155d3d75b0
First added on: Dec 12, 2015
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