Aminophylline in the treatment of acute asthma when beta 2-adrenergics and steroids are provided.

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类别 Primary study
期刊Archives of internal medicine
Year 1993
連結 Pubmed

此文章收錄於 1 Systematic review Systematic reviews (1 reference)

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背景：本研究的目的是测试的贡献氨茶碱改善呼气峰流速（PEFR）在奥西，硫酸及类固醇治疗哮喘急性发作时，还提供急诊治疗。
方法：在一项前瞻性，随机，双盲，安慰剂对照的试验，在一家市级医院急诊科，哮喘急性发作的患者44例，年龄在18岁至45岁，与茶碱水平低于28μmol/ L的，未能实现一个PEFR的40％预测后1雾化奥西治疗，被招募。氨茶碱或安慰剂负荷剂量和维持输注给药。所有患者均接受每小时雾化奥西和初始甲泼尼龙琥珀酸钠。PEFR测定每小时5小时。两因素重复测量分析的改善PEFR变异（最后初始的PEFR] /预测PEFR）进行了评估。
结果：在任何时间治疗组和安慰剂组之间无显着差异的PEFR的改善。5小时后，改善率的差异为0.40（氨茶碱）比0.36（安慰剂）（P = 0.30，N = 22，各组）。治疗组出现震颤，恶心，呕吐，心悸（P <0.05）。
结论：在急诊室，氨茶碱贡献没有显着改善，PEFR，当β-受体激动剂和糖皮质激素，而导致更多的副作用。
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Epistemonikos ID: d53bf9a7f9ad097d379e19caf1e92e47955bfccf
First added on: Dec 23, 2012
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