A controlled trial of high dose interferon, alone and after prednisone withdrawal, in the treatment of chronic hepatitis B: long term follow up.

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作者 Perez V, Findor J, Tanno H, Sordá J
类别 Primary study
期刊Gut
Year 1993
連結 Pubmed, DOI, PubMed Central

此文章收錄於 1 Systematic review Systematic reviews (1 reference)

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本研究的目的是评价其安全性和有效性的高剂量干扰素，与，或不强的松预处理，在患者与慢性B型肝炎患者被随机分为两组：第一组（n = 26）接受6周的强的松两个星期，药物无期，10万台（MU）的干扰素α-2b干扰素三次，每周皮下注射，共16周;组II组（n = 24）作为对照，为期24周，然后用干扰素治疗。在I组16 26例（61.5％），乙型肝炎e抗原（HBeAg）和乙型肝炎病毒（HBV）DNA的亏损，回归到正常的谷丙转氨酶（ALT）的活性，被视为在一组II患者（4.2％）在控制阶段，而在第二组23例（56.5％）后干扰素13。26（11.5％）23（4.3％），第二组I组和消除表面抗原（HBsAg）。响应I和II组之间差异无统计学意义。 20例患者进行肝活检显示，应答者显着减少炎症和肝组织中核心抗原消失，变化不无应答者。长期（四年），9 28应答者（32.1％）消除乙肝表面抗原，和，四个初始无应答了一晚的血清学转换。
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Epistemonikos ID: f423824f764a67d41e447cbb8ac44b0b97e894c1
First added on: Nov 26, 2012
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